This grant, offered by the National Institutes of Health, is designed to support critical research focused on the complex role of defective HIV proviruses. Its primary purpose is to thoroughly define the impact these proviruses have on the mechanisms of HIV persistence and pathogenesis, especially in individuals undergoing antiretroviral treatment. A key area of investigation includes understanding their potential deleterious effects on current and emerging HIV cure strategies, as well as their capacity to interfere with the accuracy of HIV-specific molecular assays. By funding these studies, the grant seeks to deepen our scientific understanding of HIV persistence, which is essential for developing more effective treatments and ultimately achieving a definitive cure for HIV.
Opportunity ID: 357590
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-330 |
| Funding Opportunity Title: | Role of Defective Proviruses in HIV Persistence (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Food and Nutrition Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 09, 2024 |
| Last Updated Date: | Dec 09, 2024 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | $500,000 |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Private institutions of higher education Public and State controlled institutions of higher education Small businesses Native American tribal governments (Federally recognized) For profit organizations other than small businesses Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities County governments Special district governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this notice of funding opportunity (NOFO) is to support research to define the impact of defective HIV proviruses on mechanisms of HIV persistence and pathogenesis during antiretroviral treatment and their potential deleterious effects on HIV cure strategies and interference with HIV-specific molecular assays. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-330.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357590 Full Announcement-PAR-25-330 -> PAR-25-330-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289520 | Apr 07, 2025 | Jan 07, 2028 | View |
Package 1
Mandatory forms
357590 RR_SF424_5_0-5.0.pdf
357590 PHS398_CoverPageSupplement_5_0-5.0.pdf
357590 PerformanceSite_4_0-4.0.pdf
357590 RR_KeyPersonExpanded_4_0-4.0.pdf
357590 PHS398_ResearchPlan_5_0-5.0.pdf
357590 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357590 RR_Budget_3_0-3.0.pdf
357590 RR_SubawardBudget30_3_0-3.0.pdf
357590 PHS398_ModularBudget_1_2-1.2.pdf
357590 PHS_AssignmentRequestForm_4_0-4.0.pdf
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