The National Institutes of Health (NIH) is offering this grant to promote collaborations in developing 3D biofabricated tissue models for screening non-addictive treatments for nociception, opioid use disorder, and overdose. The focus is on utilizing biofabrication technologies to create tissue constructs with human iPSC-derived cells to mimic sensory neurons, brain regions, and the blood-brain barrier. The grant supports both the development (UH2 phase) and implementation of drug screening (UH3 phase) using these models. This opportunity is part of the NIH HEAL Initiative aimed at addressing the national opioid crisis through improved addiction treatment and enhanced pain management.
Opportunity ID: 310970
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-TR-19-005 |
| Funding Opportunity Title: | HEAL Initiative: Biofabricated 3D Tissue Models of Nociception, Opioid Use Disorder and Overdose for Drug Screening (UH2/UH3 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.350 — National Center for Advancing Translational Sciences |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 10, 2018 |
| Last Updated Date: | Dec 10, 2018 |
| Original Closing Date for Applications: | Feb 28, 2019 |
| Current Closing Date for Applications: | Feb 28, 2019 |
| Archive Date: | Apr 05, 2019 |
| Estimated Total Program Funding: | $1,500,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Native American tribal governments (Federally recognized) Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public housing authorities/Indian housing authorities Independent school districts State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments City or township governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to support intramural-extramural collaborations to develop and implement the use of 3D biofabricated tissue models as novel drug screening platforms and advance pre-clinical discovery and development of non-addictive treatments for nociception, opioid use disorder (OUD) and/or overdose. In particular, support during the UH2 phase is for the application of 3D biofabrication technologies to develop novel multicellular tissue constructs for drug screening by using human iPSC-derived cells representing sensory/pain neurons, brain regions, and other tissues involved in nociception, addiction and/or overdose, including tissue models of the blood-brain barrier (BBB). Support during the UH3 is for implementation of drug screens using the 3D tissue models developed during the UH2 phase. Please limit this field to a brief description of to page in length. Brevity is appreciated. This FOA is part of the of the NIHs Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative will bolster research across NIH to (1) improve treatment for opioid misuse and addiction and (2) enhance pain management. More information about the HEAL Initiative is available at: https://www.nih.gov/research-training/medical-research-initiatives/heal-initiative |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-19-005.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00246776 | Jan 28, 2019 | Feb 28, 2019 | View |
Package 1
Mandatory forms
310970 RR_SF424_2_0-2.0.pdf
310970 PHS398_CoverPageSupplement_4_0-4.0.pdf
310970 RR_OtherProjectInfo_1_4-1.4.pdf
310970 PerformanceSite_2_0-2.0.pdf
310970 RR_KeyPersonExpanded_2_0-2.0.pdf
310970 RR_Budget_1_4-1.4.pdf
310970 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
310970 RR_SubawardBudget30_1_4-1.4.pdf
310970 PHS_AssignmentRequestForm_2_0-2.0.pdf
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