This funding opportunity from the NIH HEAL Initiative is designed to accelerate the discovery and development of safe, effective, and non-addictive therapeutics for pain treatment. The grant specifically targets initial translational research, aiming to advance promising projects to a stage where they meet the rigorous entry criteria for the Pain Therapeutics Development Program. Key activities supported include the establishment of robust assay systems, high-throughput screening for identifying novel therapeutic hits, and comprehensive initial characterization of these potential agents, which may span small molecules, biologics, and natural products. This vital initiative is dedicated to fostering innovative solutions for chronic pain management.
Opportunity ID: 356460
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-25-023 |
| Funding Opportunity Title: | HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Food and Nutrition Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 18, 2024 |
| Last Updated Date: | Sep 18, 2024 |
| Original Closing Date for Applications: | Jan 15, 2027 |
| Current Closing Date for Applications: | Jan 15, 2027 |
| Archive Date: | Feb 20, 2027 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $350,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments City or township governments Private institutions of higher education For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts State governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity is part of a suite of NOFOs within the NIH HEAL Initiative to support the development of safe, effective, and non-addictive therapeutics to treat pain. The goal is to encourage initial translational efforts that will support a drug discovery program and advance projects to the point where they meet the entry criteria for the Pain Therapeutics Development Program. The scope will therefore be focused on development of assays to support a distinct testing funnel, screening efforts to identify hits, and initial characterization of hits and potential therapeutic agents (including small molecules, biologics, and natural products). |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-25-023.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356460 Full Announcement-RFA-NS-25-023 -> RFA-NS-25-023-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288375 | Dec 28, 2024 | Jan 15, 2027 | View |
Package 1
Mandatory forms
356460 RR_SF424_5_0-5.0.pdf
356460 PHS398_CoverPageSupplement_5_0-5.0.pdf
356460 RR_OtherProjectInfo_1_4-1.4.pdf
356460 PerformanceSite_4_0-4.0.pdf
356460 RR_KeyPersonExpanded_4_0-4.0.pdf
356460 RR_Budget10_3_0-3.0.pdf
356460 PHS398_ResearchPlan_5_0-5.0.pdf
356460 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356460 RR_SubawardBudget10_30_3_0-3.0.pdf
356460 PHS_AssignmentRequestForm_4_0-4.0.pdf
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