The NIH HEAL Initiative is offering this grant to fund early-stage pilot projects identifying new druggable targets for pain within the understudied druggable proteome. This grant is for generating preliminary data and tools around eligible understudied proteins, with the purpose of jumpstarting research in pain and pain management. Funding supports basic biochemical and biological work to characterize these proteins, facilitating the discovery of novel pain targets. This NOFO is part of the NIH HEAL Initiative, designed to accelerate the development of new medications addressing the opioid addiction cycle.
Opportunity ID: 357655
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-154 |
| Funding Opportunity Title: | HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 11, 2024 |
| Last Updated Date: | Dec 11, 2024 |
| Original Closing Date for Applications: | Jul 16, 2026 |
| Current Closing Date for Applications: | Jul 16, 2026 |
| Archive Date: | Aug 21, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $100,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Private institutions of higher education Small businesses County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to identify new druggable targets for pain within the understudied druggable proteome. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s) listed in this NOFO. This NOFO is intended to jumpstart research on understudied proteins within the context of pain and pain management and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins to identify new druggable targets for pain. This NOFO is part of the NIH Helping to End Addiction Long Term (HEAL) initiative to accelerate the development of novel medications to treat all aspects of the opioid addiction cycle, including progression to chronic use, withdrawal symptoms, craving, relapse, and overdose. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-154.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357655 Full Announcement-PAR-25-154 -> PAR-25-154-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289582 | Jan 16, 2025 | Jul 16, 2026 | View |
Package 1
Mandatory forms
357655 RR_SF424_5_0-5.0.pdf
357655 PHS398_CoverPageSupplement_5_0-5.0.pdf
357655 RR_OtherProjectInfo_1_4-1.4.pdf
357655 PerformanceSite_4_0-4.0.pdf
357655 RR_KeyPersonExpanded_4_0-4.0.pdf
357655 PHS398_ResearchPlan_5_0-5.0.pdf
357655 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357655 RR_Budget_3_0-3.0.pdf
357655 RR_SubawardBudget30_3_0-3.0.pdf
357655 PHS398_ModularBudget_1_2-1.2.pdf
357655 PHS_AssignmentRequestForm_4_0-4.0.pdf
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