The NIH HEAL Initiative is offering grants for creating and testing tissue chips to model nociception, addiction, and opioid use disorders using human tissues in microphysiological systems. This funding opportunity aims to advance in vitro screening platforms that closely mimic human physiology, contributing to research on opioid misuse, addiction treatment, and pain management. Part of the HEAL Initiative to address the national opioid crisis, this grant supports innovative approaches to understanding and combatting opioid-related challenges.
Opportunity ID: 310989
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-TR-19-003 |
| Funding Opportunity Title: | HEAL Initiative: Tissue Chips to Model Nociception, Addiction, and Overdose (UG3/UH3 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 10, 2018 |
| Last Updated Date: | Dec 10, 2018 |
| Original Closing Date for Applications: | Feb 28, 2019 |
| Current Closing Date for Applications: | Feb 28, 2019 |
| Archive Date: | Apr 05, 2019 |
| Estimated Total Program Funding: | $5,000,000 |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Native American tribal governments (Federally recognized) Small businesses Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education County governments Public and State controlled institutions of higher education State governments Special district governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Tissue This FOA will provide funding for Investigators to create and test devices that can model the mechanisms or effects of nociception/pain-relevant signaling, addiction, or opioid use disorders (OUDs), using human tissues in in vitro microphysiological systems (MPS). Tissue chips, or microphysiological systems, are useful and promising in vitro human-based screening platforms because they closely mimic in vivo human physiology. Tissue chips have been shown to be capable of modeling normal and diseased physiology that faithfully recapitulates responses to stressors, treatments and other perturbations. This FOA is part of the of the NIHs Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative will bolster research across NIH to (1) improve treatment for opioid misuse and addiction and (2) enhance pain management. More information about the HEAL Initiative is available at: https://www.nih.gov/research-training/medical-research-initiatives/heal-initiative. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-19-003.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | FORMS-E | PKG00246786 | Jan 28, 2019 | Feb 28, 2019 | View |
Package 1
Mandatory forms
310989 RR_SF424_2_0-2.0.pdf
310989 PHS398_CoverPageSupplement_4_0-4.0.pdf
310989 RR_OtherProjectInfo_1_4-1.4.pdf
310989 PerformanceSite_2_0-2.0.pdf
310989 RR_KeyPersonExpanded_2_0-2.0.pdf
310989 RR_Budget_1_4-1.4.pdf
310989 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
310989 RR_SubawardBudget30_1_4-1.4.pdf
310989 PHS_AssignmentRequestForm_2_0-2.0.pdf
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