This grant from the NIH Institutes and Centers is for researching the origins and effects of low-level chronic inflammation in age-related diseases. Chronic inflammation, marked by elevated pro-inflammatory factors, is a significant risk factor in aging, yet the specific phenotypes generating it and how it compromises cellular integrity leading to disease progression remain unclear. The role of nutrition in this process is also understudied. This funding aims to clarify the molecular and cellular basis for increased inflammatory factors with aging, and establish the cause-effect relationship between inflammation and disease. Research utilizing pre-clinical models is encouraged to build this essential knowledge base for better understanding this complex interplay.
Opportunity ID: 235654
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-13-233 |
| Funding Opportunity Title: | Chronic Inflammation and Age-related Disease (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Environment Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | May 30, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Sep 07, 2014 |
| Current Closing Date for Applications: | Sep 07, 2014 |
| Archive Date: | Oct 08, 2014 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Native American tribal governments (Federally recognized) Private institutions of higher education City or township governments Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The participating NIH Institutes and Centers invite applications to address both the origins and the effects of low level chronic inflammation in the onset and progression of age-related diseases and conditions. Chronic inflammation, as defined by elevated levels of both local and systemic cytokines and other pro-inflammatory factors, is a hallmark of aging in virtually all higher animals including humans and is recognized as a major risk factor for developing age-associated diseases. The spectra of phenotypes capable of generating low-level chronic inflammation and their defining mediators are not clear. Further, a clear understanding of how chronic inflammation compromises the integrity of cells or tissues leading to disease progression is lacking. The role of dietary supplements and/or nutritional status in chronic inflammation in age-related disease is also poorly studied. Thus, there is a critical need to establish the knowledge base that will allow a better understanding of the complex interplay between inflammation and age-related diseases. Applications submitted to this FOA should aim to clarify the molecular and cellular basis for the increase in circulating inflammatory factors with aging, and/or shed light on the cause-effect relationship between inflammation and disease, using pre-clinical (animal or cellular based) models. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-13-233.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | Use for due dates after 9/24/2013 | PKG00179828 | Sep 05, 2013 | Sep 07, 2014 | View |
Package 1
Mandatory forms
235654 RR_SF424_2_0-2.0.pdf
235654 PHS398_ResearchPlan_2_0-2.0.pdf
235654 PHS398_CoverPageSupplement_2_0-2.0.pdf
235654 RR_KeyPersonExpanded_2_0-2.0.pdf
235654 RR_OtherProjectInfo_1_3-1.3.pdf
235654 PerformanceSite_2_0-2.0.pdf
Optional forms
235654 RR_SubawardBudget30_1_3-1.3.pdf
235654 PlannedReport-1.0.pdf
235654 PHS398_CumulativeInclusionReport-1.0.pdf
235654 PHS398_ModularBudget_1_2-1.2.pdf
235654 RR_Budget_1_3-1.3.pdf
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