The National Institutes of Health aims to explore the impact of genetic variants linked to Alzheimer’s disease on human neural cells. By utilizing human induced pluripotent stem cells and cell reprogramming techniques, researchers will investigate the genotype-phenotype relationship to uncover molecular targets relevant to AD. This grant seeks to bridge the gap between genetic studies and cellular biology to enhance our understanding of the mechanisms behind Alzheimer’s disease. Closing date for applications is February 10, 2017.
Opportunity ID: 289649
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-17-053 |
| Funding Opportunity Title: | Human Cell Biology of Genetic Variants in Alzheimer’s Disease (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 21, 2016 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Feb 10, 2017 |
| Current Closing Date for Applications: | Feb 10, 2017 |
| Archive Date: | Mar 13, 2017 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Small businesses Private institutions of higher education County governments Public and State controlled institutions of higher education State governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this FOA is to establish functional genotype-phenotype relationships of genetic variants, suspected of altering the risk of Alzheimers disease (AD), in neural cells using human induced pluripotent stem cells or other human cell reprogramming approaches. The causal linkage of AD-associated genetic variants identified in genome-wide association studies and genome sequencing studies to molecular and biological cell phenotypes in human neural cells is expected to give greater insight into molecular targets contributing to the etiology of AD. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-17-053.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-D | Use for due dates on or after May 25, 2016 | PKG00228720 | Jan 10, 2017 | Feb 10, 2017 | View |
Package 1
Mandatory forms
289649 RR_SF424_2_0-2.0.pdf
289649 PHS398_CoverPageSupplement_3_0-3.0.pdf
289649 RR_OtherProjectInfo_1_3-1.3.pdf
289649 PerformanceSite_2_0-2.0.pdf
289649 RR_KeyPersonExpanded_2_0-2.0.pdf
289649 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
289649 RR_Budget_1_3-1.3.pdf
289649 RR_SubawardBudget30_1_3-1.3.pdf
289649 PHS398_ModularBudget_1_2-1.2.pdf
289649 PHS_Inclusion_Enrollment_Report-1.0.pdf
289649 PHS_AssignmentRequestForm-1.0.pdf
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