This grant from the National Institutes of Health aims to fund research exploring how the gut microbiome impacts metabolism, reproduction, and fertility status. Researchers will investigate the role of gut microbiome in regulating the HPG, HPA, and HPT axes in the brain, potentially leading to the development of diagnostic markers for reproductive and metabolic health. The study aligns with various portfolios in the Fertility and Infertility Branch, focusing on ovarian biology, fertility preservation, assisted reproductive technology, spermatogenesis, and therapeutic interventions for infertility. The grant also targets the impact of gut microbiome on reproduction-related disorders like obesity, metabolic syndrome, stress disorders, infection, and anxiety, appealing to other branches such as Maternal and Pediatric Infectious Disease, Pediatric Growth and Nutrition, and IDDB.
Opportunity ID: 306576
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-18-839 |
| Funding Opportunity Title: | Role of Gut Microbiome in Regulating Reproduction and Its Impact on Fertility Status in Women Living with and Without HIV (R21 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.865 — Child Health and Human Development Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 26, 2018 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Sep 07, 2021 |
| Current Closing Date for Applications: | Sep 07, 2021 |
| Archive Date: | Oct 13, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Public and State controlled institutions of higher education For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments State governments Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) County governments Public housing authorities/Indian housing authorities Small businesses Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from the scientific community to support outstanding research related to the role of the gut microbiome in regulating metabolism and reproduction, and its impact on the fertility status. The overarching goal is to gain fundamental insight into the possible role of the gut microbiome in regulating reproduction through HPG, HPA, and HPT axes in the brain. The results of the study could lead to development of diagnostic markers (signature microbiomes) for reproductive and metabolic failure. The project is pertinent to multiple portfolios in the Fertility and Infertility Branch, e.g., basic ovarian biology, fertility preservation, assisted reproductive technology, spermatogenesis and sperm function, and therapeutic interventions to infertility. The emphasis on the gut microbiome and its impact on reproduction through its effects on HPG, HPA, and HPT axes leading to obesity, metabolic syndrome, stress disorders, infection and anxiety is also of interest to the Maternal and Pediatric infectious disease Branch, Pediatric Growth and Nutrition Branch and IDDB. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-18-839.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-E | Use for due dates on or before May 24, 2020 | PKG00243387 | Sep 16, 2018 | May 24, 2020 | View | |
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00259937 | Sep 16, 2018 | Sep 07, 2021 | View |
Package 1
Mandatory forms
306576 RR_SF424_2_0-2.0.pdf
306576 PHS398_CoverPageSupplement_4_0-4.0.pdf
306576 RR_OtherProjectInfo_1_4-1.4.pdf
306576 PerformanceSite_2_0-2.0.pdf
306576 RR_KeyPersonExpanded_2_0-2.0.pdf
306576 PHS398_ResearchPlan_4_0-4.0.pdf
Optional forms
306576 RR_Budget_1_4-1.4.pdf
306576 RR_SubawardBudget30_1_4-1.4.pdf
306576 PHS398_ModularBudget_1_2-1.2.pdf
306576 PHS_AssignmentRequestForm_2_0-2.0.pdf
Package 2
Mandatory forms
306576 RR_SF424_2_0-2.0.pdf
306576 PHS398_CoverPageSupplement_5_0-5.0.pdf
306576 RR_OtherProjectInfo_1_4-1.4.pdf
306576 PerformanceSite_2_0-2.0.pdf
306576 RR_KeyPersonExpanded_2_0-2.0.pdf
306576 PHS398_ResearchPlan_4_0-4.0.pdf
306576 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
306576 RR_Budget_1_4-1.4.pdf
306576 RR_SubawardBudget30_1_4-1.4.pdf
306576 PHS398_ModularBudget_1_2-1.2.pdf
306576 PHS_AssignmentRequestForm_3_0-3.0.pdf
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