This grant is for supporting basic and clinical studies that explore the intricate relationship between the gut microbiome, gut immune system, and central nervous system in people living with HIV (PLWH). Specifically, it aims to uncover the mechanisms by which HIV-induced alterations in the gut microbiota and immune system contribute to mental health co-morbidities. The primary purpose is to investigate how these gut factors modulate brain functions, neural circuits, neurotransmitters, signaling pathways, and synaptic plasticity. This research is crucial for understanding the pathogenesis of neurological complications and mental health issues in PLWH, especially concerning the impact of anti-retroviral therapy, ultimately leading to improved patient outcomes.
Opportunity ID: 339794
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-MH-22-230 |
| Funding Opportunity Title: | Understanding the role of Gut Immune dysfunction and Gut Microbiome in pathogenesis of Central Nervous System co-morbidities in people living with HIV (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Apr 25, 2022 |
| Last Updated Date: | Apr 25, 2022 |
| Original Closing Date for Applications: | Nov 18, 2022 |
| Current Closing Date for Applications: | Nov 18, 2022 |
| Archive Date: | Dec 24, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses County governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Public and State controlled institutions of higher education Private institutions of higher education City or township governments Special district governments State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This initiative is to support Basic and clinical studies to identify mechanisms by which gut microbiota/ gut immune system altered by HIV impact mental health outcomes in people living with HIV. The goal of this initiative is to investigate mechanisms by which the gut microbiome and gut immune system modulates the brain functions, circuits, neurotransmitters, signaling pathways and synaptic plasticity in the context of HIV and Anti-retroviral therapy. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-22-230.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00273681 | Oct 18, 2022 | Nov 18, 2022 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00278180 | Nov 08, 2022 | Nov 18, 2022 | View |
Package 1
Mandatory forms
339794 RR_SF424_5_0-5.0.pdf
339794 PHS398_CoverPageSupplement_5_0-5.0.pdf
339794 RR_OtherProjectInfo_1_4-1.4.pdf
339794 PerformanceSite_4_0-4.0.pdf
339794 RR_KeyPersonExpanded_4_0-4.0.pdf
339794 PHS398_ResearchPlan_4_0-4.0.pdf
339794 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
339794 RR_Budget_3_0-3.0.pdf
339794 RR_SubawardBudget30_3_0-3.0.pdf
339794 PHS398_ModularBudget_1_2-1.2.pdf
339794 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
339794 RR_SF424_5_0-5.0.pdf
339794 PHS398_CoverPageSupplement_5_0-5.0.pdf
339794 RR_OtherProjectInfo_1_4-1.4.pdf
339794 PerformanceSite_4_0-4.0.pdf
339794 RR_KeyPersonExpanded_4_0-4.0.pdf
339794 PHS398_ResearchPlan_5_0-5.0.pdf
339794 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
339794 RR_Budget_3_0-3.0.pdf
339794 RR_SubawardBudget30_3_0-3.0.pdf
339794 PHS398_ModularBudget_1_2-1.2.pdf
339794 PHS_AssignmentRequestForm_3_0-3.0.pdf
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