The National Cancer Institute (NCI) of the National Institutes of Health (NIH) is offering this grant to advance the clinical application of multi-analyte molecular signatures derived from comprehensive tumor annotations. This initiative aims to translate complex molecular data (DNA, RNA, protein) into practical clinical tools for improved cancer treatment. Despite proven correlations, integrating these signatures clinically remains challenging. The grant seeks to build on existing demonstrations, creating accessible publications and datasets to inform future clinical trials and foster commercialization for public health benefit. NCI encourages strategic, multi-disciplinary partnerships to enhance patient care and outcomes through molecular insights.
Opportunity ID: 78633
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-11-151 |
| Funding Opportunity Title: | Strategic Partnering to Evaluate Cancer Signatures [SPECS II] (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.394 — Cancer Detection and Diagnosis Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Mar 14, 2011 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jun 15, 2012 |
| Current Closing Date for Applications: | Jun 15, 2012 |
| Archive Date: | Jul 16, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $680,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses Private institutions of higher education Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Foreign (non-U.S.) components on applications submitted by U.S. Organizations are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA), issued by the National Cancer Institute (NCI) of the National Institutes of Health (NIH), encourages the submission of grant applications for support of the clinical application of multi-analyte molecular signatures derived from comprehensive molecular annotation of tumors. There is growing recognition in the clinical cancer research community that annotation of tumor specimens with data that integrates information about molecular alterations at the levels of DNA, RNA, and protein provides not only a more complete understanding of tumor biology but also provides a significant opportunity for developing new clinical tools to improve cancer treatment. Translating the knowledge gained from this molecular annotation into tools that can be used in clinical decision-making remains a major challenge. The purpose of this initiative is to build on recent demonstrations that molecular signatures correlate with important clinical parameters in cancer. The goal of this initiative is also to create publications and data sets that will be available and accessible to the scientific community in order to further the development, design, and conduct of future clinical trials (e.g., incorporation of molecular signatures into future clinical trials and large clinical validation studies) and to encourage appropriate commercialization to benefit the public health. The NCI invites investigators to form strategic partnerships that will bring together the multi-disciplinary expertise and resources needed to determine how the information derived from comprehensive molecular analyses can be used to improve patient care and, ultimately, patient outcomes. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-11-151.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B1 | ADOBE-FORMS-B1 | PKG00040070 | May 15, 2011 | Jun 15, 2012 | View |
Package 1
Mandatory forms
78633 RR_SF424_1_2-1.2.pdf
78633 RR_OtherProjectInfo_1_3-1.3.pdf
78633 RR_KeyPersonExpanded_1_2-1.2.pdf
78633 PerformanceSite_1_4-1.4.pdf
78633 PHS398_ResearchPlan_1_3-1.3.pdf
78633 PHS398_CoverPageSupplement_1_4-1.4.pdf
78633 PHS398_Checklist_1_3-1.3.pdf
Optional forms
78633 RR_Budget-1.1.pdf
78633 RR_SubawardBudget-1.2.pdf
78633 PHS_CoverLetter_1_2-1.2.pdf
78633 PHS398_ModularBudget-1.1.pdf
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