This NIH/NINDS StrokeNet grant funds multi-site exploratory and confirmatory clinical trials for promising stroke interventions. It also supports biomarker and outcome measure validation studies directly preparatory to trials in stroke prevention, treatment, and recovery. Ancillary studies adding scientific aims to active StrokeNet studies are also encouraged. Successful applicants will collaborate within the NIH StrokeNet infrastructure, with NINDS prioritizing top-scoring proposals. The NIH StrokeNet National Coordinating Center (NCC) will facilitate implementation, and the National Data Management Center (NDMC) will provide statistical and data management support. Regional Coordinating Centers (RCCs) and affiliated clinical sites will assist with recruitment, retention, and on-site protocol execution.
Opportunity ID: 357256
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-052 |
| Funding Opportunity Title: | NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 20, 2024 |
| Last Updated Date: | Nov 20, 2024 |
| Original Closing Date for Applications: | Nov 19, 2026 |
| Current Closing Date for Applications: | Nov 19, 2026 |
| Archive Date: | Dec 25, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses State governments City or township governments Public and State controlled institutions of higher education Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities For profit organizations other than small businesses County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This NOFO encourages applications for multi-site exploratory and confirmatory clinical trials focused on promising interventions; biomarker or outcome measure validation studies that are immediately preparatory to trials in stroke prevention, treatment, and recovery; and ancillary studies designed to add scientific aims to active studies being conducted within StrokeNet. Successful applicants will collaborate and conduct the study within the NIH StrokeNet. Following peer review, NINDS will prioritize studies among the highest scoring to be conducted in the NIH StrokeNet infrastructure. The NIH StrokeNet National Coordinating Center (NCC) will work with the successful applicant to implement the proposed study efficiently and the National Data Management Center (NDMC) will provide statistical and data management support. The NIH StrokeNet Regional Coordinating Centers (RCCs) and their affiliated clinical sites will provide recruitment/retention support as well as on-site implementation of the clinical protocol. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-052.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357256 Full Announcement-PAR-25-052 -> PAR-25-052-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288839 | Jan 18, 2025 | Nov 19, 2026 | View |
Package 1
Mandatory forms
357256 RR_SF424_5_0-5.0.pdf
357256 PHS398_CoverPageSupplement_5_0-5.0.pdf
357256 RR_OtherProjectInfo_1_4-1.4.pdf
357256 PerformanceSite_4_0-4.0.pdf
357256 RR_KeyPersonExpanded_4_0-4.0.pdf
357256 RR_Budget10_3_0-3.0.pdf
357256 PHS398_ResearchPlan_5_0-5.0.pdf
357256 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357256 RR_SubawardBudget10_30_3_0-3.0.pdf
357256 PHS_AssignmentRequestForm_4_0-4.0.pdf
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