This grant is for developing and validating harmonized methodologies to accurately measure NAD+ and related metabolite levels in human clinical trials. The focus is on establishing standardized protocols covering sample collection, storage, assay calibration, and measurement consistency across various sample types like plasma, tissue, and serum extracts. Applicants may include limited preclinical animal studies if essential for testing protocol elements before human implementation. While funded as individual awards, recipients will form a collaborative network. This network will facilitate information exchange, progress discussions, and address implementation challenges, ensuring robust and standardized measurement techniques crucial for advancing NAD+ research and its clinical applications.
Opportunity ID: 349106
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-24-039 |
| Funding Opportunity Title: | Development and Validation of Harmonized Methodologies to Measure NAD+ and Related Metabolites in Clinical Trials (U01 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 05, 2023 |
| Last Updated Date: | Jul 05, 2023 |
| Original Closing Date for Applications: | Nov 02, 2023 |
| Current Closing Date for Applications: | Nov 02, 2023 |
| Archive Date: | Dec 08, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts Special district governments For profit organizations other than small businesses Native American tribal governments (Federally recognized) Private institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments City or township governments Small businesses Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Notice of Funding Opportunity (NOFO) invites applications to develop and validate the standardized protocols for measuring nicotinamide adenine dinucleotide (NAD+) and related metabolites levels in humans, including sample collection and storage, assays calibration, and standardization of measurements across different types of samples such as plasma, tissue, or serum extracts, and validation of these protocols. Limited preclinical animal studies could be proposed by the applicants, if such studies are integral part of the applications and if they are needed to test the select elements of the standardized protocols in animal models before such protocols could be tested in humans. The proposed studies will be funded by individual awards, but the awardees will be required to interact as a network to exchange information, discuss their progress, pitfalls and issues arising during studies implementation. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-AG-24-039.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 349106 Full Announcement-RFA-AG-24-039 -> RFA-AG-24-039-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00282440 | Oct 02, 2023 | Nov 02, 2023 | View |
Package 1
Mandatory forms
349106 RR_SF424_5_0-5.0.pdf
349106 PHS398_CoverPageSupplement_5_0-5.0.pdf
349106 RR_OtherProjectInfo_1_4-1.4.pdf
349106 PerformanceSite_4_0-4.0.pdf
349106 RR_KeyPersonExpanded_4_0-4.0.pdf
349106 PHS398_ResearchPlan_5_0-5.0.pdf
349106 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
349106 RR_Budget_3_0-3.0.pdf
349106 RR_SubawardBudget30_3_0-3.0.pdf
349106 PHS398_ModularBudget_1_2-1.2.pdf
349106 PHS_AssignmentRequestForm_3_0-3.0.pdf
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