This grant, offered by the National Institutes of Health, is designed to propel early-stage, milestone-driven translational research in drug discovery. Its primary purpose is the development of novel therapeutics specifically targeting select fungal pathogens. These include critical species such as Candida auris, Aspergillus fumigatus, Coccidioides, and Mucorales. The funding employs a unique biphasic award mechanism, combining R21 and R33 phases. Progression from the initial R21 phase to the subsequent R33 phase is strictly contingent upon the successful achievement of predefined research milestones, ensuring a focused and results-oriented development pipeline for urgently needed antifungal treatments.
Opportunity ID: 356499
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-24-065 |
| Funding Opportunity Title: | Discovery and Development of Novel Therapeutics for Select Fungal Pathogens (R21/R33 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 23, 2024 |
| Last Updated Date: | Sep 23, 2024 |
| Original Closing Date for Applications: | Jan 28, 2025 |
| Current Closing Date for Applications: | Jan 28, 2025 |
| Archive Date: | Mar 05, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Small businesses Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Native American tribal governments (Federally recognized) City or township governments Special district governments County governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this notice of funding opportunity (NOFO) is to support milestone-driven, early-stage translational research focused on drug discovery and development of novel therapeutics against select fungal pathogens including: Candida species, specifically Candida auris; Aspergillus fumigatus; Coccidioides; and Mucorales. This NOFO will use a milestone-driven, biphasic award mechanism. Transition to the R33 phase will depend on the successful completion of specific milestones during the R21 phase. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-24-065.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356499 Full Announcement-RFA-AI-24-065 -> RFA-AI-24-065-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288377 | Dec 28, 2024 | Jan 28, 2025 | View |
Package 1
Mandatory forms
356499 RR_SF424_5_0-5.0.pdf
356499 PHS398_CoverPageSupplement_5_0-5.0.pdf
356499 RR_OtherProjectInfo_1_4-1.4.pdf
356499 PerformanceSite_4_0-4.0.pdf
356499 RR_KeyPersonExpanded_4_0-4.0.pdf
356499 RR_Budget10_3_0-3.0.pdf
356499 PHS398_ResearchPlan_5_0-5.0.pdf
356499 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356499 RR_SubawardBudget10_30_3_0-3.0.pdf
356499 PHS_AssignmentRequestForm_4_0-4.0.pdf
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