This grant is for the renewal of the Multicenter Osteoarthritis Study (MOST) for another five-year funding period. MOST represents a uniquely valuable, large-scale observational cohort of 3026 individuals aged 50-79, either with knee osteoarthritis (OA) at baseline or at high risk of developing it. This pioneering study has prospectively examined knee OA development and progression concerning biomechanical factors and structural abnormalities. Over seven years, it has collected extensive repeated clinical, musculoskeletal, radiographic, and MRI data, alongside strength and physical performance measures, and plasma samples. The study also established a crucial specimen bank, facilitating future biochemical and genetic biomarker research in OA, thus significantly advancing understanding of this disease.
Opportunity ID: 239469
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-13-320 |
| Funding Opportunity Title: | Limited Competition: Multicenter Osteoarthritis Study (MOST) (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Aug 07, 2013 |
| Last Updated Date: | Sep 11, 2013 |
| Original Closing Date for Applications: | Sep 07, 2017 |
| Current Closing Date for Applications: | Sep 07, 2017 |
| Archive Date: | Oct 08, 2017 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this limited competition FOA is to allow the Multicenter Osteoarthritis Study (MOST) investigators to submit a renewal application for another 5 year funding period, providing for resubmission and possible future revision applications. This is a uniquely valuable cohort of individuals who either had knee osteoarthritis (OA) at baseline or were at high risk of developing the disease because they had one or more disease risk factors. This is the first large scale observational study in knee OA to prospectively examine the development and progression of knee OA with respect to biomechanical factors and structural abnormalities. There is more than 7 years of repeated clinical and musculoskeletal evaluations, knee radiographs and knee MRI imaging, strength measures, physical performance measures and plasma samples in 3026 individuals who were 50-79 years at enrollment. The study also created a specimen bank for future biochemical and genetic studies of biomarkers in OA. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-13-320.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Modified Eligibility requirements. | Sep 11, 2013 | |
| Sep 11, 2013 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-13-320 |
| Funding Opportunity Title: | Limited Competition: Multicenter Osteoarthritis Study (MOST) (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Aug 07, 2013 |
| Last Updated Date: | Sep 11, 2013 |
| Original Closing Date for Applications: | Sep 07, 2017 |
| Current Closing Date for Applications: | Sep 07, 2017 |
| Archive Date: | Oct 08, 2017 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this limited competition FOA is to allow the Multicenter Osteoarthritis Study (MOST) investigators to submit a renewal application for another 5 year funding period, providing for resubmission and possible future revision applications. This is a uniquely valuable cohort of individuals who either had knee osteoarthritis (OA) at baseline or were at high risk of developing the disease because they had one or more disease risk factors. This is the first large scale observational study in knee OA to prospectively examine the development and progression of knee OA with respect to biomechanical factors and structural abnormalities. There is more than 7 years of repeated clinical and musculoskeletal evaluations, knee radiographs and knee MRI imaging, strength measures, physical performance measures and plasma samples in 3026 individuals who were 50-79 years at enrollment. The study also created a specimen bank for future biochemical and genetic studies of biomarkers in OA. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-13-320.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-13-320 |
| Funding Opportunity Title: | Limited Competition: Multicenter Osteoarthritis Study (MOST) (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 11, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Sep 07, 2017 |
| Archive Date: | Oct 08, 2017 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this limited competition FOA is to allow the Multicenter Osteoarthritis Study (MOST) investigators to submit a renewal application for another 5 year funding period, providing for resubmission and possible future revision applications. This is a uniquely valuable cohort of individuals who either had knee osteoarthritis (OA) at baseline or were at high risk of developing the disease because they had one or more disease risk factors. This is the first large scale observational study in knee OA to prospectively examine the development and progression of knee OA with respect to biomechanical factors and structural abnormalities. There is more than 7 years of repeated clinical and musculoskeletal evaluations, knee radiographs and knee MRI imaging, strength measures, physical performance measures and plasma samples in 3026 individuals who were 50-79 years at enrollment. The study also created a specimen bank for future biochemical and genetic studies of biomarkers in OA. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-13-320.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.866 | FORMS-C | Forms-C | PKG00182662 | Oct 05, 2013 | May 07, 2016 | View |
| FORMS-D | Use for due dates on or after May 25, 2016 | PKG00222205 | May 05, 2016 | Sep 07, 2017 | View |
Package 1
Mandatory forms
239469 RR_SF424_2_0-2.0.pdf
239469 PHS398_ResearchPlan_2_0-2.0.pdf
239469 PHS398_CoverPageSupplement_2_0-2.0.pdf
239469 RR_KeyPersonExpanded_2_0-2.0.pdf
239469 RR_OtherProjectInfo_1_3-1.3.pdf
239469 PerformanceSite_2_0-2.0.pdf
Optional forms
239469 RR_SubawardBudget30_1_3-1.3.pdf
239469 PlannedReport-1.0.pdf
239469 PHS398_CumulativeInclusionReport-1.0.pdf
239469 PHS398_ModularBudget_1_2-1.2.pdf
239469 RR_Budget_1_3-1.3.pdf
Package 2
Mandatory forms
239469 RR_SF424_2_0-2.0.pdf
239469 PHS398_CoverPageSupplement_3_0-3.0.pdf
239469 RR_OtherProjectInfo_1_3-1.3.pdf
239469 PerformanceSite_2_0-2.0.pdf
239469 RR_KeyPersonExpanded_2_0-2.0.pdf
239469 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
239469 RR_Budget_1_3-1.3.pdf
239469 RR_SubawardBudget30_1_3-1.3.pdf
239469 PHS398_ModularBudget_1_2-1.2.pdf
239469 PHS_Inclusion_Enrollment_Report-1.0.pdf
239469 PHS_AssignmentRequestForm-1.0.pdf
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