The National Institutes of Health (NIH) offers the Research Project Grant (Parent R01) to support distinct, investigator-initiated research. This grant is for projects that align with the programmatic interests and scientific missions of participating NIH Institutes and Centers. It provides funding for well-defined, circumscribed projects reflecting the investigator’s specific competencies. This opportunity exclusively supports basic, translational, or public health research that does not involve clinical trials. Applicants must ensure their proposals clearly exclude clinical trial components to be eligible for this grant, which aims to advance knowledge in areas vital to NIH’s mission.
Opportunity ID: 357812
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-25-301 |
| Funding Opportunity Title: | NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Environment Food and Nutrition Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 18, 2024 |
| Last Updated Date: | Dec 18, 2024 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public housing authorities/Indian housing authorities Special district governments State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments City or township governments Small businesses Independent school districts Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions. This Notice of Funding Opportunity does not accept applications proposing clinical trial(s). |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PA-25-301.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357812 Full Announcement-PA-25-301 -> PA-25-301-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289737 | Jan 05, 2025 | Jan 07, 2028 | View |
Package 1
Mandatory forms
357812 RR_SF424_5_0-5.0.pdf
357812 PHS398_CoverPageSupplement_5_0-5.0.pdf
357812 RR_OtherProjectInfo_1_4-1.4.pdf
357812 PerformanceSite_4_0-4.0.pdf
357812 RR_KeyPersonExpanded_4_0-4.0.pdf
357812 PHS398_ResearchPlan_5_0-5.0.pdf
357812 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357812 RR_Budget_3_0-3.0.pdf
357812 RR_SubawardBudget30_3_0-3.0.pdf
357812 PHS398_ModularBudget_1_2-1.2.pdf
357812 PHS_AssignmentRequestForm_4_0-4.0.pdf