This grant is designed to support mechanistic investigations into Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) associated protein structures. While current structural biology methods often rely on purified samples, which may not fully represent physiologically relevant protein diversity, this funding aims to advance in situ characterization techniques. This allows for the study of specific macromolecular assemblies and protein aggregates directly within their native cellular and tissue environments. Gaining structural information in a natural context is crucial for facilitating rational structure-based ligand development. The ultimate purpose is to address the critical need for novel PET ligands capable of specifically identifying and monitoring the accumulation of aggregated and misfolded proteins in AD/ADRD patients, thereby enhancing diagnostic and therapeutic strategies.
Opportunity ID: 354716
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-24-234 |
| Funding Opportunity Title: | Mechanistic Investigations into ADRD Associated Protein Structures in Biological Settings (R01 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 05, 2024 |
| Last Updated Date: | Jun 05, 2024 |
| Original Closing Date for Applications: | Oct 04, 2024 |
| Current Closing Date for Applications: | Oct 04, 2024 |
| Archive Date: | Nov 09, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Public housing authorities/Indian housing authorities State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) City or township governments Public and State controlled institutions of higher education Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Advances in structural biology have enabled the characterization of large protein assemblies that are linked to AD/ADRD pathology. However, most structural biology approaches require purified samples from cells and tissues or use recombinant bacterial proteins. The derived structures using ex-vivo material may not report the diversity of physiologically relevant species because reconstruction relies on class averaging that is biased towards dominant conformations that survive methodological processing. Recent developments in structural biology offer the possibility of in situ characterization of specific macromolecular assemblies. Structural information of protein assemblies and aggregates in their native cellular and tissue environments could facilitate rational structure-based ligand development. Currently, PET ligands that specifically identify and monitor the accumulation of aggregated and misfolded proteins in AD/ADRD patients are lacking. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-24-234.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 354716 Full Announcement-PAR-24-234 -> PAR-24-234-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00286859 | Sep 04, 2024 | Oct 04, 2024 | View |
Package 1
Mandatory forms
354716 RR_SF424_5_0-5.0.pdf
354716 PHS398_CoverPageSupplement_5_0-5.0.pdf
354716 RR_OtherProjectInfo_1_4-1.4.pdf
354716 PerformanceSite_4_0-4.0.pdf
354716 RR_KeyPersonExpanded_4_0-4.0.pdf
354716 PHS398_ResearchPlan_5_0-5.0.pdf
354716 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
354716 RR_Budget_3_0-3.0.pdf
354716 RR_SubawardBudget30_3_0-3.0.pdf
354716 PHS398_ModularBudget_1_2-1.2.pdf
354716 PHS_AssignmentRequestForm_3_0-3.0.pdf
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