The National Institutes of Health (NIH) is offering the SIREN Neurologic Clinical Trials Grant, a significant opportunity to support multi-center clinical trials focused on critical neurological emergencies. This grant is designed for researchers to effectively conduct trials in collaboration with the established NIH SIREN Network. Successful applicants will receive comprehensive support from the SIREN Clinical Coordinating Center for efficient trial implementation, while the Data Coordinating Center will provide essential statistical and data management assistance. Furthermore, SIREN hubs and their affiliated clinical sites will ensure robust on-site protocol execution. The network also fosters collaboration with other consortia for larger, definitive trials of promising interventions. Applicants are not required to be part of the current SIREN infrastructure.
Opportunity ID: 357036
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-049 |
| Funding Opportunity Title: | NIH SIREN Neurologic Clinical Trials (UG3/UH3 – Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 07, 2024 |
| Last Updated Date: | Nov 07, 2024 |
| Original Closing Date for Applications: | Mar 06, 2026 |
| Current Closing Date for Applications: | Mar 06, 2026 |
| Archive Date: | Apr 11, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments City or township governments For profit organizations other than small businesses State governments Private institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Small businesses Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This announcement (NOFO) encourages applications for multi-center clinical trials focused on neurological emergencies. Successful applicants will collaborate and conduct the trial within the NIH SIREN Network. The NIH SIREN Clinical Coordinating Center (CCC) will work with the successful applicants to implement the proposed trial efficiently and the SIREN Data Coordinating Center (DCC) will provide statistical and data management support. The NIH SIREN hubs and their affiliated clinical sites will provide on-site implementation of the clinical protocols. The NIH SIREN Network will also be uniquely poised to collaborate with other US and international consortia necessary to conduct larger, definitive trials of promising interventions for neurological emergencies. Multi-center clinical trials in stroke treatment, recovery, or prevention supported by NINDS will be conducted in the NIH StrokeNet, and not within SIREN. Applicants do not need to be part of the existing SIREN infrastructure to apply under this FOA. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-049.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
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