This grant is for the purpose of supporting exploratory research into the complex mechanisms of HIV infection, replication, latency, and pathogenesis, specifically within the challenging context of Substance Use Disorders (SUDs). The funding aims to advance understanding of how SUDs influence various aspects of HIV, including its initial infection, how it replicates in the body, its ability to remain dormant (latency), and the development of related diseases, such as HIV-Associated Neurocognitive Disorders (HAND). This broad Request for Applications (RFA) encourages innovative studies that delve into the underlying biological and pathological pathways connecting HIV and substance use, ultimately seeking new insights to inform prevention and treatment strategies for affected populations. The initiative prioritizes mechanistic questions to deepen our knowledge.
Opportunity ID: 356371
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DA-25-073 |
| Funding Opportunity Title: | Exploratory Studies to Investigate Mechanisms of HIV infection, Replication, Latency, and/or Pathogenesis in the Context of Substance Use Disorders (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.279 — Drug Abuse and Addiction Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 09, 2024 |
| Last Updated Date: | Sep 09, 2024 |
| Original Closing Date for Applications: | Aug 14, 2025 |
| Current Closing Date for Applications: | Aug 14, 2025 |
| Archive Date: | Sep 19, 2025 |
| Estimated Total Program Funding: | $2,000,000 |
| Award Ceiling: | $700,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses City or township governments Public housing authorities/Indian housing authorities Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Independent school districts Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) County governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This broad RFA will support exploratory studies addressing mechanistic questions in HIV infection, replication, latency, and/or pathogenesis (including HAND) in the context of SUDs. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-073.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356371 Full Announcement-RFA-DA-25-073 -> RFA-DA-25-073-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288371 | Jul 14, 2025 | Aug 14, 2025 | View |
Package 1
Mandatory forms
356371 RR_SF424_5_0-5.0.pdf
356371 PHS398_CoverPageSupplement_5_0-5.0.pdf
356371 RR_OtherProjectInfo_1_4-1.4.pdf
356371 PerformanceSite_4_0-4.0.pdf
356371 RR_KeyPersonExpanded_4_0-4.0.pdf
356371 PHS398_ResearchPlan_5_0-5.0.pdf
356371 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356371 RR_Budget_3_0-3.0.pdf
356371 RR_SubawardBudget30_3_0-3.0.pdf
356371 PHS398_ModularBudget_1_2-1.2.pdf
356371 PHS_AssignmentRequestForm_4_0-4.0.pdf
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