This grant, offered by the National Institute of Mental Health (NIMH) and the National Institute on Aging (NIA), supports the discovery of novel compounds for preventing and treating nervous system disorders. It encourages research spanning the entire early drug development pipeline. Specifically, funding is available for projects focused on the identification, design, synthesis, and preclinical testing of therapeutic candidates. This includes initial ‘hit-to-lead’ chemistry to enhance compound activity and later-stage ‘lead optimization’ to improve efficacy and pharmacokinetics. Additionally, the grant supports initial drug metabolism and pharmacokinetic (DMPK) studies. A strong emphasis is placed on proposals that introduce innovative methods for identifying potential therapeutic agents against these debilitating conditions.
Opportunity ID: 336765
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-031 |
| Funding Opportunity Title: | Drug Discovery For Nervous System Disorders (R01 Clinical Trials Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 29, 2021 |
| Last Updated Date: | Nov 29, 2021 |
| Original Closing Date for Applications: | Jan 07, 2025 |
| Current Closing Date for Applications: | Jan 07, 2025 |
| Archive Date: | Feb 12, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses County governments Public and State controlled institutions of higher education Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities City or township governments Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Reissue of PAR-19-147 This Funding Opportunity Announcement (FOA) supports the discovery of novel compounds for the prevention and treatment of nervous system disorders. Through this FOA NIMH and NIA wish to stimulate research in: 1) Identification, design, synthesis, and preclinical testing of compounds of candidate therapeutics; 2) Initial hit-to-lead chemistry to improve activity of compounds against the target of interest; 3) Later stage lead optimization to improve efficacy and pharmacokinetics; and 4) Initial drug metabolism and pharmacokinetic (DMPK). Emphasis will be placed on projects that provide novel approaches for identifying potential therapeutic agents. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-22-031.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 336765 Full Announcement-PAR-22-031 -> PAR-22-031-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00270648 | Jan 05, 2022 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or before January 24, 2025 | PKG00277787 | Nov 01, 2022 | Jan 24, 2025 | View |
Package 1
Mandatory forms
336765 RR_SF424_5_0-5.0.pdf
336765 PHS398_CoverPageSupplement_5_0-5.0.pdf
336765 RR_OtherProjectInfo_1_4-1.4.pdf
336765 PerformanceSite_4_0-4.0.pdf
336765 RR_KeyPersonExpanded_4_0-4.0.pdf
336765 PHS398_ResearchPlan_4_0-4.0.pdf
336765 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
336765 RR_Budget_3_0-3.0.pdf
336765 RR_SubawardBudget30_3_0-3.0.pdf
336765 PHS398_ModularBudget_1_2-1.2.pdf
336765 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
336765 RR_SF424_5_0-5.0.pdf
336765 PHS398_CoverPageSupplement_5_0-5.0.pdf
336765 RR_OtherProjectInfo_1_4-1.4.pdf
336765 PerformanceSite_4_0-4.0.pdf
336765 RR_KeyPersonExpanded_4_0-4.0.pdf
336765 PHS398_ResearchPlan_5_0-5.0.pdf
336765 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
336765 RR_Budget_3_0-3.0.pdf
336765 RR_SubawardBudget30_3_0-3.0.pdf
336765 PHS398_ModularBudget_1_2-1.2.pdf
336765 PHS_AssignmentRequestForm_3_0-3.0.pdf
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