The National Institute of Mental Health (NIMH) is offering this grant to fund research employing computational approaches to validate dimensional constructs within its Research Domain Criteria (RDoC) matrix. This initiative seeks to comprehensively validate these constructs using data-driven methods. Proposals should address how different behavioral domains segregate, their reliance on distinct versus overlapping neural circuits, and the relationships between domains, constructs, and subconstructs. The ultimate goal is to test integrative models, identify psychopathology-related dysregulation across traditional diagnoses, and advance translational research. This will lead to novel classification approaches and effective, timely interventions for serious mental illness.
Opportunity ID: 334599
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-21-263 |
| Funding Opportunity Title: | Computational Approaches for Validating Dimensional Constructs of Relevance to Psychopathology (R01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Jul 07, 2021 |
| Last Updated Date: | Sep 25, 2023 |
| Original Closing Date for Applications: | Nov 01, 2023 |
| Current Closing Date for Applications: | Sep 25, 2023 |
| Archive Date: | Oct 25, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Small businesses Independent school districts City or township governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: |
Reissue of RFA-MH-19-242.This Funding Opportunity Announcement (FOA) solicits proposals for research projects that will use computational approaches to test the validity of dimensional constructs in the NIMH Research Domain Criteria matrix (or similar constructs based on comparable criteria). Some elements of the RDoC matrix have been updated since its first release, but a thorough data-driven validation that broadly explores, compares, and validates the constructs within the matrix has not been performed. This FOA seeks research that addresses the following questions: do the different domains of behavior segregate from each other? How much do they rely on distinct vs. overlapping neural circuits? What are the relationships between domains, constructs and subordinate subconstructs, both in terms of their correlational structure and their underlying neural circuitry? By answering these questions, proposals will test integrative models of functioning and identify dysregulation in psychopathology-related mechanisms that may cut across traditional diagnostic categories and may change over time. This FOA seeks to promote projects where the computational and the experimental components are well-integrated. The ultimate goal is to advance translational research that will identify novel classification approaches and/or treatment targets, and lead to more effective and timely interventions for serious mental illness. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-21-263.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| expired and re-issued | Sep 25, 2023 | |
| Jul 07, 2021 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-21-263 |
| Funding Opportunity Title: | Computational Approaches for Validating Dimensional Constructs of Relevance to Psychopathology (R01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Jul 07, 2021 |
| Last Updated Date: | Sep 25, 2023 |
| Original Closing Date for Applications: | Nov 01, 2023 |
| Current Closing Date for Applications: | Sep 25, 2023 |
| Archive Date: | Oct 25, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Small businesses Independent school districts City or township governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: |
Reissue of RFA-MH-19-242.This Funding Opportunity Announcement (FOA) solicits proposals for research projects that will use computational approaches to test the validity of dimensional constructs in the NIMH Research Domain Criteria matrix (or similar constructs based on comparable criteria). Some elements of the RDoC matrix have been updated since its first release, but a thorough data-driven validation that broadly explores, compares, and validates the constructs within the matrix has not been performed. This FOA seeks research that addresses the following questions: do the different domains of behavior segregate from each other? How much do they rely on distinct vs. overlapping neural circuits? What are the relationships between domains, constructs and subordinate subconstructs, both in terms of their correlational structure and their underlying neural circuitry? By answering these questions, proposals will test integrative models of functioning and identify dysregulation in psychopathology-related mechanisms that may cut across traditional diagnostic categories and may change over time. This FOA seeks to promote projects where the computational and the experimental components are well-integrated. The ultimate goal is to advance translational research that will identify novel classification approaches and/or treatment targets, and lead to more effective and timely interventions for serious mental illness. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-21-263.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-21-263 |
| Funding Opportunity Title: | Computational Approaches for Validating Dimensional Constructs of Relevance to Psychopathology (R01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 07, 2021 |
| Last Updated Date: | Jul 07, 2021 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Nov 01, 2023 |
| Archive Date: | Dec 07, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments Independent school districts Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education For profit organizations other than small businesses Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) City or township governments Public housing authorities/Indian housing authorities County governments Special district governments Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Reissue of RFA-MH-19-242.This Funding Opportunity Announcement (FOA) solicits proposals for research projects that will use computational approaches to test the validity of dimensional constructs in the NIMH Research Domain Criteria matrix (or similar constructs based on comparable criteria). Some elements of the RDoC matrix have been updated since its first release, but a thorough data-driven validation that broadly explores, compares, and validates the constructs within the matrix has not been performed. This FOA seeks research that addresses the following questions: do the different domains of behavior segregate from each other? How much do they rely on distinct vs. overlapping neural circuits? What are the relationships between domains, constructs and subordinate subconstructs, both in terms of their correlational structure and their underlying neural circuitry? By answering these questions, proposals will test integrative models of functioning and identify dysregulation in psychopathology-related mechanisms that may cut across traditional diagnostic categories and may change over time. This FOA seeks to promote projects where the computational and the experimental components are well-integrated. The ultimate goal is to advance translational research that will identify novel classification approaches and/or treatment targets, and lead to more effective and timely interventions for serious mental illness. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-21-263.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Related Documents
Folder 334599 Full Announcement-PAR-21-263 -> PAR-21-263-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00268084 | Oct 01, 2021 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00269813 | Oct 28, 2021 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00277761 | Nov 01, 2022 | Sep 26, 2023 | View |
Package 1
Mandatory forms
334599 RR_SF424_2_0-2.0.pdf
334599 PHS398_CoverPageSupplement_5_0-5.0.pdf
334599 RR_OtherProjectInfo_1_4-1.4.pdf
334599 PerformanceSite_2_0-2.0.pdf
334599 RR_KeyPersonExpanded_2_0-2.0.pdf
334599 PHS398_ResearchPlan_4_0-4.0.pdf
334599 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
334599 RR_Budget_1_4-1.4.pdf
334599 RR_SubawardBudget30_1_4-1.4.pdf
334599 PHS398_ModularBudget_1_2-1.2.pdf
334599 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
334599 RR_SF424_5_0-5.0.pdf
334599 PHS398_CoverPageSupplement_5_0-5.0.pdf
334599 RR_OtherProjectInfo_1_4-1.4.pdf
334599 PerformanceSite_4_0-4.0.pdf
334599 RR_KeyPersonExpanded_4_0-4.0.pdf
334599 PHS398_ResearchPlan_4_0-4.0.pdf
334599 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
334599 RR_Budget_3_0-3.0.pdf
334599 RR_SubawardBudget30_3_0-3.0.pdf
334599 PHS398_ModularBudget_1_2-1.2.pdf
334599 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 3
Mandatory forms
334599 RR_SF424_5_0-5.0.pdf
334599 PHS398_CoverPageSupplement_5_0-5.0.pdf
334599 RR_OtherProjectInfo_1_4-1.4.pdf
334599 PerformanceSite_4_0-4.0.pdf
334599 RR_KeyPersonExpanded_4_0-4.0.pdf
334599 PHS398_ResearchPlan_5_0-5.0.pdf
334599 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
334599 RR_Budget_3_0-3.0.pdf
334599 RR_SubawardBudget30_3_0-3.0.pdf
334599 PHS398_ModularBudget_1_2-1.2.pdf
334599 PHS_AssignmentRequestForm_3_0-3.0.pdf
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