This grant is for advancing the understanding of HIV-1 persistence and neuropathogenesis within the Central Nervous System (CNS), particularly in the context of effective antiretroviral therapy (ART). A primary focus is on eradicating latent HIV reservoirs and elucidating mechanisms behind HIV-associated CNS co-morbidities, which persist despite virologic control. The research aims to explore how HIV targets the CNS early in infection, leading to neurological impairments. It will investigate the critical roles of CD4+ T cells and monocytes in mediating HIV entry, persistence, and neuronal damage within the brain, as well as the involvement of CD8+ T cells in viral replication control in the CNS. This initiative seeks to address the continuing challenges of HIV persistence and neuroinflammation in the CNS.
Opportunity ID: 357290
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-MH-26-111 |
| Funding Opportunity Title: | Role of T-Cells in HIV CNS Reservoir Seeding, Persistence, and Neuropathogenesis (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 21, 2024 |
| Last Updated Date: | Nov 21, 2024 |
| Original Closing Date for Applications: | Mar 18, 2025 |
| Current Closing Date for Applications: | Mar 18, 2025 |
| Archive Date: | Apr 23, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses Special district governments Public and State controlled institutions of higher education County governments Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Private institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Eradicating latent reservoirs of HIV-1 within the body and achieving a sterilizing or functional cure have become priority areas in the AIDS field and NIH AIDS programs across many Institutes and Centers, including NIMH. In addition understanding the mechanisms of HIV- associated co-morbidities in the setting of effective anti-retroviral therapy (ART) is a major topic of interest in the field. HIV Associated CNS (central nervous system) co-morbidities continue to exist despite excellent virologic control in this compartment. HIV persistence and neuroinflammation also continues to observed in the CNS in the setting of ART. HIV targets the CNS early in infection, and HIV-infected individuals suffer from mild forms of neurological impairments even under antiretroviral therapy (ART). CD4+ T cells and monocytes mediate HIV entry into the brain and constitute a source for HIV persistence and neuronal damage. CD8+ T cells are also massively recruited in the CNS in acute infection to control viral replication. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-26-111.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357290 Full Announcement-RFA-MH-26-111 -> RFA-MH-26-111-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288870 | Feb 17, 2025 | Mar 18, 2025 | View |
Package 1
Mandatory forms
357290 RR_SF424_5_0-5.0.pdf
357290 PHS398_CoverPageSupplement_5_0-5.0.pdf
357290 RR_OtherProjectInfo_1_4-1.4.pdf
357290 PerformanceSite_4_0-4.0.pdf
357290 RR_KeyPersonExpanded_4_0-4.0.pdf
357290 PHS398_ResearchPlan_5_0-5.0.pdf
357290 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357290 RR_Budget_3_0-3.0.pdf
357290 RR_SubawardBudget30_3_0-3.0.pdf
357290 PHS398_ModularBudget_1_2-1.2.pdf
357290 PHS_AssignmentRequestForm_4_0-4.0.pdf
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