The National Institute of Mental Health (NIMH) is offering this grant to support pilot effectiveness studies for mental health interventions. This grant is for researchers focusing on optimizing the effectiveness of previously proven preventive and therapeutic interventions for wider populations or community use. It also aims to fund the development and preliminary testing of innovative mental health service interventions. Consistent with NIMH’s experimental therapeutics approach, proposals must explicitly investigate whether the intervention engages the specific mechanisms presumed to drive its effects, such as changes in clinical outcomes, provider behavior, or service access. This initiative is a crucial part of NIMH’s clinical trials pipeline.
Opportunity ID: 357422
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-178 |
| Funding Opportunity Title: | Pilot Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 27, 2024 |
| Last Updated Date: | Nov 27, 2024 |
| Original Closing Date for Applications: | Oct 15, 2027 |
| Current Closing Date for Applications: | Oct 15, 2027 |
| Archive Date: | Nov 20, 2027 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Private institutions of higher education County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education State governments Independent school districts Small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Pilot Effectiveness Trials for Treatment, Preventive and Services Interventions (R01 Clinical Trial Required). As part of NIMH’s clinical trials pipeline NOFOs, this announcement encourages pilot effectiveness studies focused on 1) optimizing the effectiveness of preventive and therapeutic interventions with previously demonstrated efficacy, for use with broader target populations or for use in community practice settings, and 2) developing and preliminary testing innovative services interventions. Consistent with the NIMH experimental therapeutics approach, this NOFO is intended to support pilot studies of intervention effectiveness or service delivery approaches that explicitly address whether the intervention engages the target(s)/mechanism(s) presumed to underlie the intervention effects (i.e., the mechanism(s) that accounts for changes in clinical/functional outcomes, changes in provider behavior, improved access or continuity of services, etc.). |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-178.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357422 Full Announcement-PAR-25-178 -> PAR-25-178-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289143 | Jan 14, 2025 | Oct 15, 2027 | View |
Package 1
Mandatory forms
357422 RR_SF424_5_0-5.0.pdf
357422 PHS398_CoverPageSupplement_5_0-5.0.pdf
357422 RR_OtherProjectInfo_1_4-1.4.pdf
357422 PerformanceSite_4_0-4.0.pdf
357422 RR_KeyPersonExpanded_4_0-4.0.pdf
357422 PHS398_ResearchPlan_5_0-5.0.pdf
357422 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357422 RR_Budget_3_0-3.0.pdf
357422 RR_SubawardBudget30_3_0-3.0.pdf
357422 PHS398_ModularBudget_1_2-1.2.pdf
357422 PHS_AssignmentRequestForm_4_0-4.0.pdf
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