This grant, offered by the National Institute of Mental Health (NIMH), is for developing and testing novel psychosocial therapeutic and preventive interventions for mental disorders. It specifically encourages pilot research consistent with NIMH’s experimental therapeutics approach, aiming to accelerate the translation of basic behavioral and neuropsychological science into clinical applications. The R61/R33 mechanism provides up to two years of support for evaluating target engagement and establishing intervention parameters. Following this, projects can receive up to three years to replicate target engagement from prior studies and thoroughly test its association with changes in clinical outcomes. This initiative is a crucial part of NIMH’s clinical trials pipeline, fostering new and effective mental health solutions.
Opportunity ID: 357427
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-182 |
| Funding Opportunity Title: | Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 27, 2024 |
| Last Updated Date: | Nov 27, 2024 |
| Original Closing Date for Applications: | Oct 15, 2027 |
| Current Closing Date for Applications: | Oct 15, 2027 |
| Archive Date: | Nov 20, 2027 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) Private institutions of higher education Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments City or township governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required). As part of NIMH’s clinical trials pipeline, this NOFO encourages pilot research developing and testing novel psychosocial interventions and/or targets. Consistent with NIMH’s emphasis on the experimental therapeutics approach to intervention development, it intends to speed the translation of emergent research in basic, behavioral, cognitive, affect, and neuropsychological science into preventative or therapeutic interventions. This RFA will provide up to two years of support for evaluation of target engagement and establishment of intervention parameters, and up to three years of support to replicate target engagement from prior studies and to test the association between target engagement and change in clinical outcome(s). |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-182.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357427 Full Announcement-PAR-25-182 -> PAR-25-182-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289156 | Jan 18, 2025 | Oct 15, 2027 | View |
Package 1
Mandatory forms
357427 RR_SF424_5_0-5.0.pdf
357427 PHS398_CoverPageSupplement_5_0-5.0.pdf
357427 RR_OtherProjectInfo_1_4-1.4.pdf
357427 PerformanceSite_4_0-4.0.pdf
357427 RR_KeyPersonExpanded_4_0-4.0.pdf
357427 RR_Budget10_3_0-3.0.pdf
357427 PHS398_ResearchPlan_5_0-5.0.pdf
357427 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357427 RR_SubawardBudget10_30_3_0-3.0.pdf
357427 PHS_AssignmentRequestForm_4_0-4.0.pdf
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