The National Institute of Neurological Diseases and Stroke (NINDS) is offering a grant to establish a genome-wide association study consortium focused on identifying genes influencing the risk and outcome of ischemic stroke. This grant aims to create a global resource of genotyping data for ischemic stroke cases, emphasizing the need for rigorously phenotyped samples. The consortium will develop standardized methods for subtype assignment and enable future subtype-specific studies, data mining, and hypothesis generation. Applicants must plan for a Data Coordinating Center and Genetic Research Centers to provide an adequate number of genotyped samples for meaningful GWAS analysis, with a focus on utilizing existing DNA sample sets. Closing Date: May 15, 2009.
Opportunity ID: 45514
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-09-002 |
| Funding Opportunity Title: | NINDS Ischemic Stroke Genetics Consortium (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 26, 2009 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | May 15, 2009 |
| Current Closing Date for Applications: | May 15, 2009 |
| Archive Date: | Jun 15, 2009 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $900,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education County governments Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Native American tribal governments (Federally recognized) Independent school districts State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Small businesses Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose.This funding opportunity announcement (FOA) issued by the National Institute of Neurological Diseases and Stroke (NINDS), the National Institutes of Health (NIH) solicits grant applications from institutions/ organizations that propose to establish a genome-wide association study consortium focused on the goal of identifying genes that influence the risk and outcome of ischemic stroke.The NINDS will support one such multi-center consortium.This project will create a permanent global resource, via the Database of Genotype and Phenotype (dbGAP), of genotyping data of rigorously phenotyped ischemic stroke cases.The proposed study should concentrate on using existing DNA sample sets.Each application submitted in response to this FOA must include plans to establish:(i) a Data Coordinating Center (DCC) and (ii) Genetic Research Centers (GRC) that together would be able to make available a sufficient number of genotyped and uniformly phenotyped samples to provide statistical power for a meaningful GWAS analysis (6,000 or more samples is an estimate of an appropriate sample size).The Consortium should develop standardized, validated, and easily replicated methods to assign stroke subtypes for this GWAS analysis.The samples submitted for this GWAS should be accompanied by clinical data to support the endophenotyping in this study and more importantly, to enable the utilization of the data from these study in future subtype-specific studies.The goal of this announcement is not only to enable an initial exploration of genes that affect susceptibility and outcome, but also to create a national resource of high quality information for data mining, replication studies, and future hypothesis generation. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-09-002.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
There are no packages on this grant.
Share This Post, Choose Your Platform!
About the Author: osnqt
