This NINDS grant invites applications to test promising cerebrovascular interventions within the Stroke Preclinical Assessment Network (SPAN). This grant facilitates the rigorous preclinical evaluation of up to eight cerebroprotective drugs or interventions, administered prior to or at reperfusion in experimental ischemic stroke models. Awarded PIs will join the SPAN network, collaborating with a Coordinating Center and testing laboratories for parallel assessments. Applicants must propose an intervention supported by robust preliminary data. This initiative aims to accelerate the identification of effective cerebroprotective therapies, bridging preclinical testing with future clinical trials efficiently, and advancing stroke treatment.
Opportunity ID: 337232
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-22-032 |
| Funding Opportunity Title: | Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies For Acute Cerebroprotection- Interventions (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 06, 2022 |
| Last Updated Date: | Jan 06, 2022 |
| Original Closing Date for Applications: | Mar 14, 2022 |
| Current Closing Date for Applications: | Mar 14, 2022 |
| Archive Date: | Apr 19, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities County governments Small businesses City or township governments For profit organizations other than small businesses Independent school districts Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this funding opportunity announcement (FOA) is to invite applications for research projects to test promising cerebrovascular interventions in the NINDS Stroke Preclinical Assessment Network (SPAN). SPAN will facilitate the testing of up to 8 promising cerebroprotective drugs or interventions to be given prior to or at the time of reperfusion in experimental models of ischemic stroke (e.g., transient middle cerebral artery occlusion, tMCAo). The PIs of the awarded interventions will become part of the network and will collaborate with the SPAN Coordinating Center (RFA-NS-22-004), testing laboratories (RFA-NS-22-003), and other intervention contributors (RFA-NS-22-032, RFA-NS-22-033) to facilitate the parallel testing of multiple cerebroprotective interventions in experimental models of ischemic stroke. Applicants must propose a promising cerebroprotective intervention, supported by rigorous and extensive preliminary data, to be tested in SPAN. If successful, this network will accelerate the identification of the most promising cerebroprotective therapies for future pivotal clinical trials and span the gap between small businesses, preclinical testing laboratories, and a pipeline to clinical testing, in a cost-and time-effective fashion. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-032.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 337232 Full Announcement-RFA-NS-22-032 -> RFA-NS-22-032-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00272227 | Feb 25, 2022 | Mar 14, 2022 | View |
Package 1
Mandatory forms
337232 RR_SF424_5_0-5.0.pdf
337232 PHS398_CoverPageSupplement_5_0-5.0.pdf
337232 RR_OtherProjectInfo_1_4-1.4.pdf
337232 PerformanceSite_4_0-4.0.pdf
337232 RR_KeyPersonExpanded_4_0-4.0.pdf
337232 PHS398_ResearchPlan_4_0-4.0.pdf
337232 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
337232 RR_Budget_3_0-3.0.pdf
337232 RR_SubawardBudget30_3_0-3.0.pdf
337232 PHS398_ModularBudget_1_2-1.2.pdf
337232 PHS_AssignmentRequestForm_3_0-3.0.pdf
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