The National Institute of Neurological Disorders and Stroke (NINDS) is offering Innovation Grants to Nurture Initial Translational Efforts (IGNITE). This grant provides funding for critical pharmacodynamic, pharmacokinetic, and in vivo efficacy studies. Its purpose is to characterize and demonstrate sufficient biological activity of proposed therapeutic agents, such as small molecules, biologics, or biotechnology products. These agents are intended for treating neurological or neuromuscular disorders within the NINDS mission. This program aims to advance early-stage projects to a point where they can enter subsequent translational initiatives like the Blueprint Neurotherapeutics Network, thereby accelerating the development of new neurotherapeutics.
Opportunity ID: 356953
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-225 |
| Funding Opportunity Title: | Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Neurotherapeutic Agent Characterization and In vivo Efficacy Studies (R61/R33 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 04, 2024 |
| Last Updated Date: | Nov 04, 2024 |
| Original Closing Date for Applications: | Oct 20, 2027 |
| Current Closing Date for Applications: | Oct 20, 2027 |
| Archive Date: | Nov 25, 2027 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments Special district governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses City or township governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses County governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Reissue PAR-21-122. This NOFO provides funding to conduct pharmacodynamic, pharmacokinetic, and in vivo efficacy studies to demonstrate that proposed therapeutic agent(s) have sufficient biological activity to warrant further development to treat neurological or neuromuscular disorders that fall under the NINDS mission. Therapeutic agents include small molecules, biologics or biotechnology-derived products. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) to advance projects to the point where they can meet the entry criteria for the Blueprint Neurotherapeutics Network or other translational programs. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-225.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356953 Full Announcement-PAR-25-225 -> PAR-25-225-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288452 | Jan 19, 2025 | Oct 20, 2027 | View |
Package 1
Mandatory forms
356953 RR_SF424_5_0-5.0.pdf
356953 PHS398_CoverPageSupplement_5_0-5.0.pdf
356953 RR_OtherProjectInfo_1_4-1.4.pdf
356953 PerformanceSite_4_0-4.0.pdf
356953 RR_KeyPersonExpanded_4_0-4.0.pdf
356953 RR_Budget10_3_0-3.0.pdf
356953 PHS398_ResearchPlan_5_0-5.0.pdf
356953 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356953 RR_SubawardBudget10_30_3_0-3.0.pdf
356953 PHS_AssignmentRequestForm_4_0-4.0.pdf
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