This grant is for small businesses to test promising cerebroprotective interventions within the National Institute of Neurological Disorders and Stroke (NINDS) Stroke Preclinical Assessment Network (SPAN). The purpose is to facilitate the parallel testing of up to eight interventions in experimental ischemic stroke models, administered prior to or at reperfusion. Awarded PIs will collaborate with SPAN’s coordinating center and testing laboratories. This network aims to accelerate the identification of promising cerebroprotective therapies for future pivotal clinical trials, bridging the gap between small businesses, preclinical development, and clinical testing in a cost- and time-effective manner.
Opportunity ID: 337253
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-22-033 |
| Funding Opportunity Title: | Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Cerebroprotection- Interventions from Small Businesses (U44 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 06, 2022 |
| Last Updated Date: | Jan 06, 2022 |
| Original Closing Date for Applications: | Mar 14, 2022 |
| Current Closing Date for Applications: | Mar 14, 2022 |
| Archive Date: | Apr 19, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $300,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed. See Full Announcement for eligibility details |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this funding opportunity announcement (FOA) is to invite applications for Phase II SBIR applications to test promising cerebrovascular interventions in the NINDS Stroke Preclinical Assessment Network (SPAN). SPAN will facilitate the testing of up to 8 promising cerebroprotective drugs or interventions to be given prior to or at the time of reperfusion in experimental models of ischemic stroke (e.g., transient middle cerebral artery occlusion (tMCAo)). The PIs of the awarded interventions will become part of the network and will collaborate with the SPAN Coordinating Center (RFA-NS-22-004), testing laboratories (RFA-NS-22-003), and other intervention contributors (RFA-NS-22-032) to facilitate the parallel testing of multiple cerebroprotective interventions in experimental models of ischemic stroke. Applicants must propose a research project involving a promising cerebroprotective intervention, supported by rigorous and extensive preliminary data, to be tested in SPAN. If successful, this network will accelerate the identification of the most promising cerebroprotective therapies for future pivotal clinical trials and span the gap between small businesses, preclinical testing laboratories, and a pipeline to clinical testing, in a cost-and time-effective fashion. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-033.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 337253 Full Announcement-RFA-NS-22-033 -> RFA-NS-22-033-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00271236 | Feb 14, 2022 | Mar 14, 2022 | View |
Package 1
Mandatory forms
337253 RR_SF424_5_0-5.0.pdf
337253 PHS398_CoverPageSupplement_5_0-5.0.pdf
337253 RR_OtherProjectInfo_1_4-1.4.pdf
337253 PerformanceSite_4_0-4.0.pdf
337253 RR_KeyPersonExpanded_4_0-4.0.pdf
337253 RR_Budget_3_0-3.0.pdf
337253 PHS398_ResearchPlan_4_0-4.0.pdf
337253 SBIR_STTR_Information_3_0-3.0.pdf
337253 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
337253 RR_SubawardBudget30_3_0-3.0.pdf
337253 PHS_AssignmentRequestForm_3_0-3.0.pdf
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