This NINDS grant aims to develop a federated, open-source software platform for broad sharing and advanced analysis of human digital neuropathological slides in AD/ADRD research. The platform will establish tools and standards for a single access point to slides from multiple brain banks, enabling multisite analyses. This includes validating software for cross-site annotation and computational image analysis. A key purpose is widespread data sharing as a digital resource. All software adheres to Open Science, and the digital library follows FAIR data principles, fostering collaborative research.
Opportunity ID: 343015
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-22-062 |
| Funding Opportunity Title: | Connecting Machine Readable Digital Human AD/ADRD Neuropathological Library Platforms for Advanced Analytics (U24 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 09, 2022 |
| Last Updated Date: | Aug 09, 2022 |
| Original Closing Date for Applications: | Nov 04, 2022 |
| Current Closing Date for Applications: | Nov 04, 2022 |
| Archive Date: | Dec 10, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $650,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Private institutions of higher education Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts State governments County governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this NINDS-led Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) initiative is to 1) develop tools, standards, and an Open-source software platform that enables a federated (multiple data repository sites with a single access portal) approach for data sharing and analysis of human digital neuropathological slides and 2) perform software testing to validate and verify that the software and tools developed can be used to perform multisite neuropathological analyses using a federated approach. The federated approach requires a single access point of digital slides from multiple geographically distinct brain banks. The resources developed are expected to also enable cross-site annotation and computational image analysis, including advanced analytic approaches. A critical feature of this FOA includes the broad sharing of neuropathological data to further advance research in this area, including the development of a digital resource for distribution and sharing of assessed neuropathological tissue. Software and tools developed under this initiative are expected to be shared using Open Science principles, and the federated digital library is expected to follow FAIR data sharing principles. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-062.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 343015 Full Announcement-RFA-NS-22-062 -> RFA-NS-22-062-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00276321 | Oct 04, 2022 | Nov 04, 2022 | View |
Package 1
Mandatory forms
343015 RR_SF424_5_0-5.0.pdf
343015 PHS398_CoverPageSupplement_5_0-5.0.pdf
343015 RR_OtherProjectInfo_1_4-1.4.pdf
343015 PerformanceSite_4_0-4.0.pdf
343015 RR_KeyPersonExpanded_4_0-4.0.pdf
343015 RR_Budget_3_0-3.0.pdf
343015 PHS398_ResearchPlan_4_0-4.0.pdf
343015 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343015 RR_SubawardBudget30_3_0-3.0.pdf
343015 PHS_AssignmentRequestForm_3_0-3.0.pdf
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