The Oncology Research Department is offering this Translational and Basic Science Research in Early Lesions (TBEL) grant to integrate basic and translational cancer research concepts. This grant is for the purpose of examining the causal relationships and interactions of early lesions, their microenvironment, and host-systemic factors in tumor initiation and progression. The ultimate goals are to deepen understanding of biological and pathophysiological mechanisms driving or restraining precancers and early cancers, and to facilitate biology-backed precision prevention approaches. Utilizing the U54 Cooperative Agreements, each TBEL Center will pursue a unique thematic focus, testing hypotheses that bridge basic and translational research. Collectively, these Centers will form a network to inform future, rationally-designed interventions, founded on strong biological mechanisms and tailored to the malignant potential of early lesions.
Opportunity ID: 335506
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-CA-21-054 |
| Funding Opportunity Title: | Translational and Basic Science Research in Early Lesions (TBEL) (U54 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.394 — Cancer Detection and Diagnosis Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 31, 2021 |
| Last Updated Date: | Aug 31, 2021 |
| Original Closing Date for Applications: | Nov 02, 2021 |
| Current Closing Date for Applications: | Nov 02, 2021 |
| Archive Date: | Dec 08, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $1,000,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Special district governments City or township governments Public housing authorities/Indian housing authorities County governments Private institutions of higher education Native American tribal governments (Federally recognized) Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The TBEL program aims to integrate basic and translational cancer research concepts to examine the direct causal relationships and interactions of an early lesion, its microenvironment and host-systemic factors as co-organizers of tumor initiation (or suppression) and malignant progression. The ultimate goals of the TBEL program are to further understand the biological and pathophysiological mechanisms driving or restraining precancers and early cancers and facilitate biology-backed precision prevention approaches. The FOA will utilize the U54 (Specialized Center–Cooperative Agreements) activity code. Each TBEL Center shall have a unique thematic focus and be structured to test hypotheses that bridge basic and translational research in a synergistic and iterative fashion. Collectively, TBEL Centers will operate as a network that will inform future, rationally-design modes of intervention that are founded on strong biological mechanisms and be comprehensive, multi-dimensional, and appropriately tailored to the degree of malignant potential of an early lesion. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-21-054.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00269647 | Oct 27, 2021 | Nov 02, 2021 | View | |
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00268773 | Oct 02, 2021 | Jan 24, 2022 | View |
Package 1
Mandatory forms
335506 RR_SF424_5_0-5.0.pdf
335506 PHS398_CoverPageSupplement_5_0-5.0.pdf
335506 RR_OtherProjectInfo_1_4-1.4.pdf
335506 PerformanceSite_4_0-4.0.pdf
335506 RR_KeyPersonExpanded_4_0-4.0.pdf
335506 PHS398_ResearchPlan_4_0-4.0.pdf
335506 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
335506 PHS_Additional_IndirectCosts_2_0-2.0.pdf
335506 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
335506 RR_SF424_2_0-2.0.pdf
335506 PHS398_CoverPageSupplement_5_0-5.0.pdf
335506 RR_OtherProjectInfo_1_4-1.4.pdf
335506 PerformanceSite_2_0-2.0.pdf
335506 RR_KeyPersonExpanded_2_0-2.0.pdf
335506 PHS398_ResearchPlan_4_0-4.0.pdf
335506 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
335506 PHS_Additional_IndirectCosts-1.0.pdf
335506 PHS_AssignmentRequestForm_3_0-3.0.pdf
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