Research Grant for Eradication of HIV-1 from CNS Reservoirs (R01) – NIMH, NINDS, NIAID

The NIMH, NINDS, and NIAID are offering a research grant to study HIV-1 persistence in the central nervous system (CNS) under Highly Active Anti-Retroviral Therapy. The grant aims to advance research in identifying CNS-based HIV-1 reservoirs, understanding mechanisms of establishment and resurgence, developing animal models and assays, screening drugs that penetrate the blood-brain barrier to eliminate CNS virus, and designing therapeutic strategies for HIV-1 eradication from the CNS. Applications for basic to translational research, both domestically and internationally, are welcomed. Multidisciplinary research teams are encouraged to apply. Closing date for applications is September 12, 2012.

Opportunity ID: 144853

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General Information

Document Type::	Grants Notice
Funding Opportunity Number::	RFA-MH-13-030
Funding Opportunity Title::	Eradication of HIV-1 from CNS Reservoirs: Implications for Therapeutics (R01)
Opportunity Category::	Discretionary
Opportunity Category Explanation::
Funding Instrument Type::
Category of Funding Activity::	Health
Category Explanation::
Expected Number of Awards::
Assistance Listings Number(s)::	93.242 — Mental Health Research Grants
Cost Sharing or Matching Requirement::	No
Version::	Synopsis 1
Posted Date::	Feb 17, 2012
Last Updated Date::
Original Closing Date for Applications::	Sep 12, 2012
Current Closing Date for Applications::	Sep 12, 2012
Archive Date::	Oct 13, 2012
Estimated Total Program Funding::
Award Ceiling::	$
Award Floor::	$

Eligibility

Eligible Applicants::

Private institutions of higher education

Additional Information on Eligibility::

Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name::	National Institutes of Health
Description::	The National Institute of Mental Health (NIMH), National Institute of Neurological Disorders and Stroke (NINDS), and National Institute of Allergy and Infectious Disease (NIAID) invite research grant applications to address the problem of HIV-1 persistence focused solely on the central nervous system (CNS) of HIV-infected persons treated with Highly Active Anti-Retroviral Therapy (HAART). This Funding Opportunity Announcement (FOA) will support innovative research in five areas: (1) basic research to identify and characterize CNS-based cellular reservoirs of HIV-1 for individuals on HAART; (2) basic research to determine the mechanisms involved in the temporal establishment, maintenance, and resurgence of CNS-based HIV-1 reservoirs in relationship to the effects and timing of HAART, viral expression, and viral evolution within the brain; (3) development of physiologically relevant animal models and CNS-based cellular assays that recapitulate HIV-1 persistence and latency in the presence of effective HAART; (4) drug screening of potential agents which traverse the blood-brain barrier and eliminate latent or other sources of residual virus in the CNS; and (5) design of therapeutic strategies aimed at eradication of HIV-1 from the CNS. Applications ranging from basic to translational research in domestic and international settings are of interest. Multidisciplinary research teams are encouraged but not required.
Link to Additional Information::
Grantor Contact Information::	If you have difficulty accessing the full announcement electronically, please contact:

Version History

Version	Modification Description	Updated Date
Synopsis 1

Package Status

Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:

Package No: 1

Assistance Listings:
Competition ID:	ADOBE-FORMS-B2
Competition Title:	ADOBE-FORMS-B2
Opportunity Package ID:	PKG00098250
Opening Date:	Aug 12, 2012
Closing Date:	Sep 12, 2012
Agency Contact Information::	Grants Info
Who Can Apply::	Organization Applicants
mendatory_forms	SF424 (R & R) [V1.2] Project/Performance Site Location(s) [V1.4] Research And Related Other Project Information [V1.3] Research And Related Senior/Key Person Profile (Expanded) [V1.2] PHS 398 Cover Page Supplement [V1.4] PHS 398 Research Plan [V1.3] PHS 398 Checklist [V1.3]
optional_forms	R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.2] PHS 398 Modular Budget [V1.2] Research & Related Budget [V1.1] PHS Cover Letter [V1.2]