The National Institutes of Health (NIH) has released a grant opportunity under the number RFA-MH-25-115, titled “BRAIN Initiative: Marmoset Colonies for Neuroscience Research.” This grant is part of a discretionary funding program aimed at advancing neuroscience research by expanding existing colonies of the common marmoset (Callithrix jacchus). Recognized as a valuable nonhuman primate model for understanding the primate brain, the common marmoset offers significant insights due to behavioral similarities to humans and the ability for germline transmission of genetic information.
The focus of this grant is to support the expansion of marmoset colonies in the United States, particularly for the care, breeding, and distribution of genetically modified marmosets and cryopreserved embryos and gametes produced by NIH-funded research programs. Recipients of this funding are expected not only to enlarge their current marmoset colonies but also to ensure that these animals are healthy, well-characterized, and available to the neuroscience research community. Additionally, they are required to have a plan for accepting and distributing genetically modified marmosets and cryopreserved genetic materials. A key component of this initiative is the collaboration with the NIH-Funded Marmoset Coordination Center, where recipients will contribute health and genetic information to enhance understanding and improve the genetic diversity of the captive marmoset population across various colonies. This grant represents a significant effort by the NIH to bolster neuroscience research through the strategic use of nonhuman primate models, thereby enhancing our understanding of brain function and disorders.
Opportunity ID: 351185
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-MH-25-115 |
| Funding Opportunity Title: | BRAIN Initiative: Marmoset Colonies for Neuroscience Research (U24 Clinical Trials Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Environment Health Income Security and Social Services |
| Category Explanation: | |
| Expected Number of Awards: | |
| CFDA Number(s): | 93.113 — Environmental Health 93.121 — Oral Diseases and Disorders Research 93.173 — Research Related to Deafness and Communication Disorders 93.213 — Research and Training in Complementary and Integrative Health 93.242 — Mental Health Research Grants 93.273 — Alcohol Research Programs 93.279 — Drug Abuse and Addiction Research Programs 93.286 — Discovery and Applied Research for Technological Innovations to Improve Human Health 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 — Child Health and Human Development Extramural Research 93.866 — Aging Research 93.867 — Vision Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 28, 2023 |
| Last Updated Date: | Nov 28, 2023 |
| Original Closing Date for Applications: | Mar 01, 2024 |
| Current Closing Date for Applications: | Mar 01, 2024 |
| Archive Date: | Apr 06, 2024 |
| Estimated Total Program Funding: | |
| Award Ceiling: | $ |
| Award Floor: | $ |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) For profit organizations other than small businesses Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities County governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Special district governments Private institutions of higher education City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The common marmoset (Callithrix jacchus) has emerged as a promising nonhuman primate model system to understand the primate brain. This has come about both from the realization that the behavior of the common marmoset is similar in some ways to human behavior and from recent demonstration of germline transmission of exogenous genetic information. This Notice of Funding Opportunity (NOFO) solicits applications to expand existing colonies of the common marmoset for neuroscience research in the United States, and to support the care, breeding and distribution of genetically modified marmosets, and cryopreserved embryos and gametes created by NIH-funded research programs such as the NIH BRAIN Initiative Tools for Germline Gene Editing in Marmosets research consortium. Recipients s under this NOFO are expected to expand their current marmoset colonies to provide healthy, well-characterized animals that will be made available to the neuroscience research community, and to include a plan to accept genetically modified marmosets, and cryopreserved embryos and gametes for distribution to the research community. Recipients are also expected to participate in and provide health and genetic information to an NIH-Funded Marmoset Coordination Center to help the community understand the pedigree of individuals in the captive marmoset population and improve the genetic diversity of that population across multiple colonies. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-25-115.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact: NIH Grants Information
grantsinfo@nih.gov |