This U54 Cooperative Agreement grant invites applications to establish multi-component Alzheimers Disease and Related Dementias Translational Centers for Microphysiological Systems (AD/ADRD MPS Translational Centers). The primary purpose of this grant is to foster the development of reproducible and scalable 2D and 3D models of AD/ADRD. These advanced models are expected to recapitulate key features of human AD/ADRD pathophysiology, serving as crucial precision medicine research tools. The centers will leverage these platforms to investigate the complex biology of AD/ADRD, thereby significantly accelerating multiple aspects of drug discovery and preclinical drug development efforts aimed at treating and preventing these diseases.
Opportunity ID: 350629
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-24-040 |
| Funding Opportunity Title: | Microphysiological Systems to Advance Precision Medicine for AD/ADRD Treatment and Prevention (U54 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 19, 2023 |
| Last Updated Date: | Oct 19, 2023 |
| Original Closing Date for Applications: | Feb 15, 2024 |
| Current Closing Date for Applications: | Feb 15, 2024 |
| Archive Date: | Mar 22, 2024 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $2,500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Private institutions of higher education Small businesses Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education State governments County governments Special district governments Independent school districts For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Notice of Funding Opportunity (NOFO) invites U54 Cooperative Agreement applications aiming to establish multi-component Alzheimers Disease and Related Dementias Translational Centers for Microphysiological Systems (MPS) (AD/ADRD MPS Translational Centers). The overarching purpose of this Centers program is to develop 2D and 3D models of AD/ADRD as reproducible and scalable platforms that recapitulate key features of human AD/ADRD pathophysiology to be used as precision medicine research tools to investigate the complex biology of AD/ADRD and to accelerate multiple aspects of drug discovery and preclinical drug development. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-AG-24-040.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 350629 Full Announcement-RFA-AG-24-040 -> RFA-AG-24-040-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00283549 | Jan 15, 2024 | Feb 15, 2024 | View |
Package 1
Mandatory forms
350629 RR_SF424_5_0-5.0.pdf
350629 PHS398_CoverPageSupplement_5_0-5.0.pdf
350629 RR_OtherProjectInfo_1_4-1.4.pdf
350629 PerformanceSite_4_0-4.0.pdf
350629 RR_KeyPersonExpanded_4_0-4.0.pdf
350629 PHS398_ResearchPlan_5_0-5.0.pdf
350629 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
350629 PHS_Additional_IndirectCosts_2_0-2.0.pdf
350629 PHS_AssignmentRequestForm_3_0-3.0.pdf
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