This grant advances cancer model systems recapitulating human immunity in the tumor microenvironment to enhance immuno-oncology study predictivity. Projects must focus on developing in vivo or in vitro models that regenerate or mimic the human immune system using human cells or tissues. These models should achieve a human immune system representation matching or surpassing existing murine models. Research relying solely on genetically manipulated immune systems without introducing human immune lineage cells is not eligible. This initiative seeks to improve research tools for understanding and treating cancer, fostering effective immuno-oncology therapies.
Opportunity ID: 345072
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-CA-23-015 |
| Funding Opportunity Title: | Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 22, 2022 |
| Last Updated Date: | Dec 22, 2022 |
| Original Closing Date for Applications: | Nov 17, 2023 |
| Current Closing Date for Applications: | Nov 17, 2023 |
| Archive Date: | Dec 23, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $300,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments For profit organizations other than small businesses City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Special district governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Small businesses County governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this FOA is to advance cancer model systems that recapitulate human immunity in the tumor microenvironment to improve the predictivity of immuno-oncology studies. Proposed research projects must focus on recapitulation of the human immune system in their proposed cancer model using human cells or tissues to regenerate and/or recapitulate the human immune system in in vivo or in vitro immuno-oncology models in a manner that matches or exceeds representation of the human immune system achieved with murine models developed using HFT. Models derived from genetically manipulated immune systems without introduction of human immune lineage cells will not be considered responsive.The FOA will utilize the R33 Exploratory/Developmental Grants Phase II research activity code. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-CA-23-015.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 345072 Full Announcement-RFA-CA-23-015 -> RFA-CA-23-015-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00279014 | May 13, 2023 | Nov 17, 2023 | View |
Package 1
Mandatory forms
345072 RR_SF424_5_0-5.0.pdf
345072 PHS398_CoverPageSupplement_5_0-5.0.pdf
345072 RR_OtherProjectInfo_1_4-1.4.pdf
345072 PerformanceSite_4_0-4.0.pdf
345072 RR_KeyPersonExpanded_4_0-4.0.pdf
345072 PHS398_ResearchPlan_5_0-5.0.pdf
345072 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
345072 RR_Budget_3_0-3.0.pdf
345072 RR_SubawardBudget30_3_0-3.0.pdf
345072 PHS398_ModularBudget_1_2-1.2.pdf
345072 PHS_AssignmentRequestForm_3_0-3.0.pdf
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