The HIV/Cervical Cancer Prevention ‘CASCADE’ Clinical Trials Network is offering this grant to establish clinical sites dedicated to advancing cervical cancer prevention for women living with HIV. This initiative aims to evaluate innovative approaches and overcome barriers within the cervical cancer screening and treatment cascade. The network will conduct pragmatic clinical trials to assess the effectiveness of clinically proven interventions, focusing on increasing screening uptake, improving management of screen positives, and optimizing precancer treatment access. The goal is to refine clinical practice guidelines and inform public health policy by generating crucial evidence for improved cervical cancer prevention programs. Funded UG1 Clinical Sites will provide essential infrastructure and collaborate with the network on study feasibility and clinical significance.
Opportunity ID: 336277
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-CA-21-047 |
| Funding Opportunity Title: | Clinical Sites for HIV/Cervical Cancer Prevention ‘CASCADE’ Clinical Trials Network (UG1 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 26, 2021 |
| Last Updated Date: | Oct 26, 2021 |
| Original Closing Date for Applications: | Dec 28, 2021 |
| Current Closing Date for Applications: | Dec 28, 2021 |
| Archive Date: | Feb 02, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education Small businesses Public housing authorities/Indian housing authorities Special district governments For profit organizations other than small businesses City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Independent school districts |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The HIV/Cervical Cancer Prevention ‘CASCADE’ Clinical Trials Network seeks to evaluate innovative approaches for overcoming barriers and reducing failures in the cervical cancer screening and treatment cascade for women living with HIV. The proposed multicenter network will conduct pragmatic clinical trials to evaluate the effectiveness of clinically proven interventions in intended-use settings with a goal to optimize the cervical cancer screening, management, and precancer treatment cascade for women living with HIV. These trials will focus on the health care continuum for secondary cervical cancer prevention, i.e., increasing screening uptake, improving management of screen positives, facilitating precancer treatment access, and optimizing precancer treatments. Data from these trials will be used to provide the necessary evidence to refine clinical practice guidelines and inform public health policy with a goal to generate crucial actionable evidence for improving cervical cancer prevention implementation programs. Six-to-eight UG1 cooperative agreement mechanism-funded Clinical Sites, led by clinical investigators and/or clinicians, will provide a pluripotent clinical infrastructure to conduct/implement multiple prevention clinical trials through the CASCADE network and interface with network grantees during concept and protocol development to provide insights and input on clinical significance and study feasibility. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-21-047.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00269507 | Nov 28, 2021 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00269609 | Nov 28, 2021 | Dec 28, 2021 | View |
Package 1
Mandatory forms
336277 RR_SF424_2_0-2.0.pdf
336277 PHS398_CoverPageSupplement_5_0-5.0.pdf
336277 RR_OtherProjectInfo_1_4-1.4.pdf
336277 PerformanceSite_2_0-2.0.pdf
336277 RR_KeyPersonExpanded_2_0-2.0.pdf
336277 RR_Budget_1_4-1.4.pdf
336277 PHS398_ResearchPlan_4_0-4.0.pdf
336277 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
336277 RR_SubawardBudget30_1_4-1.4.pdf
336277 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
336277 RR_SF424_5_0-5.0.pdf
336277 PHS398_CoverPageSupplement_5_0-5.0.pdf
336277 RR_OtherProjectInfo_1_4-1.4.pdf
336277 PerformanceSite_4_0-4.0.pdf
336277 RR_KeyPersonExpanded_4_0-4.0.pdf
336277 RR_Budget_3_0-3.0.pdf
336277 PHS398_ResearchPlan_4_0-4.0.pdf
336277 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
336277 RR_SubawardBudget30_3_0-3.0.pdf
336277 PHS_AssignmentRequestForm_3_0-3.0.pdf
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