The Clinical Trials in Organ Transplantation (CTOT) program invites applications from groups of two or more institutions to participate in a clinical studies program. This grant is for supporting a cooperative, multi-institutional consortium that will conduct interventional (Phase 1, 2, or 3) or observational clinical studies in organ or vascularized composite allotransplantation (VCA). Each study must include associated mechanistic research focusing on immune-mediated pathologic processes in allotransplantation or on mechanisms of immune activation and quiescence. The overarching goal is to target immune-mediated causes of morbidity and mortality in transplant recipients and evaluate interventions to address them, ultimately improving long-term outcomes.
Opportunity ID: 237976
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-13-006 |
| Funding Opportunity Title: | Clinical Trials in Organ Transplantation (CTOT) (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy, Immunology and Transplantation Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 19, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 19, 2013 |
| Current Closing Date for Applications: | Nov 19, 2013 |
| Archive Date: | Dec 20, 2013 |
| Estimated Total Program Funding: | $9,500,000 |
| Award Ceiling: | $1,750,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public and State controlled institutions of higher education Private institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Special district governments State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This FOA invites applications from groups of two (2) or more institutions to participate in a clinical studies program to improve the long-term outcome of transplant recipients (thoracic organ, abdominal organ and vascular composite tissue). The Clinical Trials in Organ Transplantation (CTOT) program will support a cooperative, multi-institutional consortium for the conduct of interventional trials (Phase 1, 2, or 3) or observational clinical studies in organ or vascularized composite allotransplantation (VCA). Each clinical study must include associated mechanistic studies that focus on immune-mediated pathologic processes in allotransplantation or on mechanisms of immune activation and quiescence. The goals of this research will be to target immune-mediated causes of morbidity and mortality in transplant recipients and evaluate interventions to address them. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-13-006.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-C | Forms-C | PKG00181350 | Oct 19, 2013 | Nov 19, 2013 | View |
Package 1
Mandatory forms
237976 RR_SF424_2_0-2.0.pdf
237976 PHS398_ResearchPlan_2_0-2.0.pdf
237976 PHS398_CoverPageSupplement_2_0-2.0.pdf
237976 RR_KeyPersonExpanded_2_0-2.0.pdf
237976 RR_OtherProjectInfo_1_3-1.3.pdf
237976 PerformanceSite_2_0-2.0.pdf
Optional forms
237976 RR_SubawardBudget30_1_3-1.3.pdf
237976 PlannedReport-1.0.pdf
237976 PHS398_CumulativeInclusionReport-1.0.pdf
237976 PHS398_ModularBudget_1_2-1.2.pdf
237976 RR_Budget_1_3-1.3.pdf
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