This grant, offered by the Department of Defense’s Clinical and Rehabilitative Medicine Research Program (CRMRP), is for supporting preclinical research and clinical trials on neuromusculoskeletal injuries. Its primary purpose is to advance the functional utility of assistive devices, focusing on improvements to the human-device interface, socket comfort, and sensory feedback. The grant also aims to improve prediction and reduction of secondary health effects after severe extremity injury, including osteoarthritis, low back pain, and fall risks. Additionally, it seeks to optimize rehabilitation strategies and device prescription to minimize impairments and maximize patient function. Projects involving unapproved drugs or devices must adhere to FDA Investigational New Drug (IND) or Investigational Device Exemption (IDE) regulations.
Opportunity ID: 245473
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | W81XWH-14-DMRDP-CRMRP-NMSIRA |
| Funding Opportunity Title: | DoD Clinical and Rehabilitative Medicine Neuromusculoskeletal Injuries Research Award |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Grant |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | 5 |
| Assistance Listings: | 12.420 — Military Medical Research and Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 3 |
| Posted Date: | Oct 25, 2013 |
| Last Updated Date: | Oct 25, 2013 |
| Original Closing Date for Applications: | Dec 23, 2013 |
| Current Closing Date for Applications: | Feb 11, 2014 |
| Archive Date: | Mar 13, 2014 |
| Estimated Total Program Funding: | $8,300,000 |
| Award Ceiling: | $0 |
| Award Floor: | $0 |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | Dept. of the Army — USAMRAA |
| Description: | The FY14 DMRDP CRMRP Neuromusculoskeletal Injuries Research Award (NMSIRA) supports preclinical research and clinical trials on the functional utility of assistive devices related to the human-device interface, secondary health effects following severe extremity injury, and optimizing rehabilitation and device prescription for patients with severe extremity trauma.To meet the intent of the award mechanism, applications must specifically address one or more of the FY14 DMRDP CRMRP NMSIRA Focus Areas listed below. Applications proposing research outside of the Focus Areas listed below should not be submitted in response to this Program Announcement/Funding Opportunity. Improving the functional utility of assistive devices related to the human-device interface (prostheses, orthoses, and other assistive devices)o Improvements in prosthetic socket comfort, residual limb health, and functiono Providing proprioceptive and other sensory inputs to the usero Improving user intent control of assistive devices Improving the ability to predict, identify and reduce secondary health effects that develop after severe primary neuromusculoskeletal injuryo Determining factors that predict development and successful treatment of osteoarthritis, low back pain, or other musculoskeletal conditionso Intervention strategies to diminish falls and decrease fracture risko Strategies to improve treatment and rehabilitation of heterotopic ossification Optimizing treatment strategies and sequence of progression throughout the rehabilitation process following severe extremity traumao Determining the optimal combination, dose, and timing of rehabilitative techniques to minimize impairments and maximize function and performanceo Objectively guiding prosthetic and/or orthotic prescription to minimize impairments and maximize function and performanceIf the proposed study involves the use of a drug or biologic that has not been approved by the Food and Drug Administration (FDA) for its investigational use, evidence that an Investigational New Drug (IND) exemption application has been submitted or will be submitted within 60 days of award is required. If the proposed study involves an Investigational Device that has not been approved or cleared by FDA for its investigational clinical use, the study may be required to comply with the FDA Investigational Device Exemption (IDE) regulations and evidence that an IDE has been submitted or will be submitted within 60 days of the award date or that the device is exempt from an IDE is required. The Government reserves the right to withdraw funding if the IND or IDE application has not been submitted to the FDA within 60 days of the DoD award date or if the documented status of the IND or IDE has not been obtained within 6 months of the award date. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
CDMRP Help Desk
301-682-5507 Email:help@cdmrp.org |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Change to application submission deadline. | Oct 25, 2013 | |
| Application Submission Deadline has been revised. | Oct 25, 2013 | |
| Oct 25, 2013 |
DISPLAYING: Synopsis 3
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | W81XWH-14-DMRDP-CRMRP-NMSIRA |
| Funding Opportunity Title: | DoD Clinical and Rehabilitative Medicine Neuromusculoskeletal Injuries Research Award |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Grant |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | 5 |
| Assistance Listings: | 12.420 — Military Medical Research and Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 3 |
| Posted Date: | Oct 25, 2013 |
| Last Updated Date: | Oct 25, 2013 |
| Original Closing Date for Applications: | Dec 23, 2013 |
| Current Closing Date for Applications: | Feb 11, 2014 |
| Archive Date: | Mar 13, 2014 |
| Estimated Total Program Funding: | $8,300,000 |
| Award Ceiling: | $0 |
| Award Floor: | $0 |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | Dept. of the Army — USAMRAA |
| Description: | The FY14 DMRDP CRMRP Neuromusculoskeletal Injuries Research Award (NMSIRA) supports preclinical research and clinical trials on the functional utility of assistive devices related to the human-device interface, secondary health effects following severe extremity injury, and optimizing rehabilitation and device prescription for patients with severe extremity trauma.To meet the intent of the award mechanism, applications must specifically address one or more of the FY14 DMRDP CRMRP NMSIRA Focus Areas listed below. Applications proposing research outside of the Focus Areas listed below should not be submitted in response to this Program Announcement/Funding Opportunity. Improving the functional utility of assistive devices related to the human-device interface (prostheses, orthoses, and other assistive devices)o Improvements in prosthetic socket comfort, residual limb health, and functiono Providing proprioceptive and other sensory inputs to the usero Improving user intent control of assistive devices Improving the ability to predict, identify and reduce secondary health effects that develop after severe primary neuromusculoskeletal injuryo Determining factors that predict development and successful treatment of osteoarthritis, low back pain, or other musculoskeletal conditionso Intervention strategies to diminish falls and decrease fracture risko Strategies to improve treatment and rehabilitation of heterotopic ossification Optimizing treatment strategies and sequence of progression throughout the rehabilitation process following severe extremity traumao Determining the optimal combination, dose, and timing of rehabilitative techniques to minimize impairments and maximize function and performanceo Objectively guiding prosthetic and/or orthotic prescription to minimize impairments and maximize function and performanceIf the proposed study involves the use of a drug or biologic that has not been approved by the Food and Drug Administration (FDA) for its investigational use, evidence that an Investigational New Drug (IND) exemption application has been submitted or will be submitted within 60 days of award is required. If the proposed study involves an Investigational Device that has not been approved or cleared by FDA for its investigational clinical use, the study may be required to comply with the FDA Investigational Device Exemption (IDE) regulations and evidence that an IDE has been submitted or will be submitted within 60 days of the award date or that the device is exempt from an IDE is required. The Government reserves the right to withdraw funding if the IND or IDE application has not been submitted to the FDA within 60 days of the DoD award date or if the documented status of the IND or IDE has not been obtained within 6 months of the award date. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
CDMRP Help Desk
301-682-5507 Email:help@cdmrp.org |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | W81XWH-14-DMRDP-CRMRP-NMSIRA |
| Funding Opportunity Title: | DoD Clinical and Rehabilitative Medicine Neuromusculoskeletal Injuries Research Award |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Grant |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | 5 |
| Assistance Listings: | 12.420 — Military Medical Research and Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Oct 25, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Dec 23, 2013 |
| Archive Date: | Jan 22, 2014 |
| Estimated Total Program Funding: | $8,300,000 |
| Award Ceiling: | $0 |
| Award Floor: | $0 |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | Dept. of the Army — USAMRAA |
| Description: | The FY14 DMRDP CRMRP Neuromusculoskeletal Injuries Research Award (NMSIRA) supports preclinical research and clinical trials on the functional utility of assistive devices related to the human-device interface, secondary health effects following severe extremity injury, and optimizing rehabilitation and device prescription for patients with severe extremity trauma. To meet the intent of the award mechanism, applications must specifically address one or more of the FY14 DMRDP CRMRP NMSIRA Focus Areas listed below. Applications proposing research outside of the Focus Areas listed below should not be submitted in response to this Program Announcement/Funding Opportunity. Improving the functional utility of assistive devices related to the human-device interface (prostheses, orthoses, and other assistive devices) o Improvements in prosthetic socket comfort, residual limb health, and function o Providing proprioceptive and other sensory inputs to the user o Improving user intent control of assistive devices Improving the ability to predict, identify and reduce secondary health effects that develop after severe primary neuromusculoskeletal injury o Determining factors that predict development and successful treatment of osteoarthritis, low back pain, or other musculoskeletal conditions o Intervention strategies to diminish falls and decrease fracture risk o Strategies to improve treatment and rehabilitation of heterotopic ossification Optimizing treatment strategies and sequence of progression throughout the rehabilitation process following severe extremity trauma o Determining the optimal combination, dose, and timing of rehabilitative techniques to minimize impairments and maximize function and performance o Objectively guiding prosthetic and/or orthotic prescription to minimize impairments and maximize function and performance If the proposed study involves the use of a drug or biologic that has not been approved by the Food and Drug Administration (FDA) for its investigational use, evidence that an Investigational New Drug (IND) exemption application has been submitted or will be submitted within 60 days of award is required. If the proposed study involves an Investigational Device that has not been approved or cleared by FDA for its investigational clinical use, the study may be required to comply with the FDA Investigational Device Exemption (IDE) regulations and evidence that an IDE has been submitted or will be submitted within 60 days of the award date or that the device is exempt from an IDE is required. The Government reserves the right to withdraw funding if the IND or IDE application has not been submitted to the FDA within 60 days of the DoD award date or if the documented status of the IND or IDE has not been obtained within 6 months of the award date. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
CDMRP Help Desk
301-682-5507 Email:help@cdmrp.org |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | W81XWH-14-DMRDP-CRMRP-NMSIRA |
| Funding Opportunity Title: | DoD Clinical and Rehabilitative Medicine Neuromusculoskeletal Injuries Research Award |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Grant |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | 5 |
| Assistance Listings: | 12.420 — Military Medical Research and Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 25, 2013 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Dec 23, 2013 |
| Archive Date: | Jan 22, 2014 |
| Estimated Total Program Funding: | $8,300,000 |
| Award Ceiling: | $0 |
| Award Floor: | $0 |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | Dept. of the Army — USAMRAA |
| Description: | The FY14 DMRDP CRMRP Neuromusculoskeletal Injuries Research Award (NMSIRA) supports preclinical research and clinical trials on the functional utility of assistive devices related to the human-device interface, secondary health effects following severe extremity injury, and optimizing rehabilitation and device prescription for patients with severe extremity trauma. To meet the intent of the award mechanism, applications must specifically address one or more of the FY14 DMRDP CRMRP NMSIRA Focus Areas listed below. Applications proposing research outside of the Focus Areas listed below should not be submitted in response to this Program Announcement/Funding Opportunity. Improving the functional utility of assistive devices related to the human-device interface (prostheses, orthoses, and other assistive devices) o Improvements in prosthetic socket comfort, residual limb health, and function o Providing proprioceptive and other sensory inputs to the user o Improving user intent control of assistive devices Improving the ability to predict, identify and reduce secondary health effects that develop after severe primary neuromusculoskeletal injury o Determining factors that predict development and successful treatment of osteoarthritis, low back pain, or other musculoskeletal conditions o Intervention strategies to diminish falls and decrease fracture risk o Strategies to improve treatment and rehabilitation of heterotopic ossification Optimizing treatment strategies and sequence of progression throughout the rehabilitation process following severe extremity trauma o Determining the optimal combination, dose, and timing of rehabilitative techniques to minimize impairments and maximize function and performance o Objectively guiding prosthetic and/or orthotic prescription to minimize impairments and maximize function and performance If the proposed study involves the use of a drug or biologic that has not been approved by the Food and Drug Administration (FDA) for its investigational use, evidence that an Investigational New Drug (IND) exemption application has been submitted or will be submitted within 60 days of award is required. If the proposed study involves an Investigational Device that has not been approved or cleared by FDA for its investigational clinical use, the study may be required to comply with the FDA Investigational Device Exemption (IDE) regulations and evidence that an IDE has been submitted or will be submitted within 60 days of the award date or that the device is exempt from an IDE is required. The Government reserves the right to withdraw funding if the IND or IDE application has not been submitted to the FDA within 60 days of the DoD award date or if the documented status of the IND or IDE has not been obtained within 6 months of the award date. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
CDMRP Help Desk
301-682-5507 Email:help@cdmrp.org |
Related Documents
Folder 245473 Full Announcement-1 -> fy13-14_ind-ide form.pdf
Folder 245473 Full Announcement-1 -> fy14 crmrp nmsira pa_gg.pdf
Packages
| Agency Contact Information: | CDMRP Help Desk 301-682-5507 Email: help@cdmrp.org |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 12.420 | PKG00187731 | Oct 25, 2013 | Feb 11, 2014 | View |
Package 1
Mandatory forms
245473 RR_SF424_1_2-1.2.pdf
245473 PerformanceSite_1_4-1.4.pdf
245473 RR_Budget-1.1.pdf
245473 RR_KeyPersonExpanded_1_2-1.2.pdf
Optional forms
245473 RR_SubawardBudget30-1.2.pdf
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