This grant is for the purpose of supporting research to understand how HIV infection, even in individuals suppressed on combination antiretroviral therapy (cART), leads to changes in immunometabolism. Specifically, it aims to elucidate how these HIV-induced immunometabolic alterations impact the host’s immune response and increase susceptibility to poor outcomes from secondary infections such as tuberculosis (TB) or hepatitis B virus (HBV). The funded research will define how these immunometabolic shifts affect immune cell regulation, interactions between cells, response to treatment, and ultimately, the progression of TB and HBV diseases. This initiative seeks to deepen our understanding of co-infection mechanisms.
Opportunity ID: 357821
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-315 |
| Funding Opportunity Title: | Elucidating Immunometabolic Responses to HIV Infection that Increase TB or HBV Risk (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 18, 2024 |
| Last Updated Date: | Dec 18, 2024 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education County governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) City or township governments Independent school districts Small businesses Special district governments Private institutions of higher education State governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this notice of funding opportunity (NOFO) is to support research to elucidate how HIV-induced immunometabolic alterations, in a host suppressed on combination antiretroviral therapy (cART-suppressed), impact the immune response and increase risk for poor outcomes due to a second, potentially long-term, infection such as Mycobacterium tuberculosis (Mtb) or hepatitis B virus (HBV). This NOFO aims to support research to define how HIV-driven alterations to immunometabolism affect immune cell regulation, cell-cell interactions, response to treatment, and, ultimately, tuberculosis (TB) and HBV disease progression. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-315.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357821 Full Announcement-PAR-25-315 -> PAR-25-315-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289746 | Apr 07, 2025 | Jan 07, 2028 | View |
Package 1
Mandatory forms
357821 RR_SF424_5_0-5.0.pdf
357821 PHS398_CoverPageSupplement_5_0-5.0.pdf
357821 RR_OtherProjectInfo_1_4-1.4.pdf
357821 PerformanceSite_4_0-4.0.pdf
357821 RR_KeyPersonExpanded_4_0-4.0.pdf
357821 PHS398_ResearchPlan_5_0-5.0.pdf
357821 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357821 RR_Budget_3_0-3.0.pdf
357821 RR_SubawardBudget30_3_0-3.0.pdf
357821 PHS398_ModularBudget_1_2-1.2.pdf
357821 PHS_AssignmentRequestForm_4_0-4.0.pdf
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