This grant from the Department of Neuroscience and Aging Research is for researchers to advance understanding of Alzheimer’s disease (AD) by investigating brain circuit susceptibility to AD-related pathology and neurodegeneration in mouse models. The funding aims to support the comprehensive characterization of these circuits and the sharing of cell connectome data in aging and AD brains. This data will be integrated into a common reference brain cell atlas, combining molecular and anatomical annotations. Furthermore, the grant seeks to expand research on vulnerable cell types, mapping connectivity changes in aging and AD, to provide deeper insights into the mechanisms underlying resilience and vulnerability to AD.
Opportunity ID: 331236
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-22-008 |
| Funding Opportunity Title: | The Cellular Scale Connectome in Aging and Alzheimers Disease (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 29, 2021 |
| Last Updated Date: | Jan 29, 2021 |
| Original Closing Date for Applications: | Jun 15, 2021 |
| Current Closing Date for Applications: | Jun 15, 2021 |
| Archive Date: | Jul 21, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Special district governments County governments Public and State controlled institutions of higher education State governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts Private institutions of higher education For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) invites applications that will: (1) promote the development of a comprehensive characterization of brain circuits susceptible to Alzheimers disease type pathology and/or neurodegeneration in mouse models of Alzheimer’s disease (AD), (2) share data on the cell connectome in the aging and AD brain in a common reference brain cell atlas that integrates both molecular and anatomical annotations, and (3) complement and extend research on vulnerable cell types to include the mapping of connectivity changes between cells in aging and AD and provide a greater understanding of the mechanisms underlying resilience and vulnerability in AD. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-22-008.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00265254 | May 15, 2021 | Jun 15, 2021 | View |
Package 1
Mandatory forms
331236 RR_SF424_2_0-2.0.pdf
331236 PHS398_CoverPageSupplement_5_0-5.0.pdf
331236 RR_OtherProjectInfo_1_4-1.4.pdf
331236 PerformanceSite_2_0-2.0.pdf
331236 RR_KeyPersonExpanded_2_0-2.0.pdf
331236 PHS398_ResearchPlan_4_0-4.0.pdf
331236 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
331236 RR_Budget_1_4-1.4.pdf
331236 RR_SubawardBudget30_1_4-1.4.pdf
331236 PHS398_ModularBudget_1_2-1.2.pdf
331236 PHS_AssignmentRequestForm_3_0-3.0.pdf
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