The Department of Defense (DOD) Multiple Sclerosis Metric Development and Validation Award is designed to foster the creation and validation of accessible, cost-effective analytical methods for quantifying MS disease, monitoring its progression, and evaluating therapy efficacy. This grant aims to accelerate advances in MS research by supporting the development of high-impact measurements that significantly improve current methods’ sensitivity and specificity, or provide novel targets. Emphasis is placed on reproducible and accurate processes, leading to metrics with broad clinical and research applications. This funding is for developing tools like biomarkers, cognitive/physical disability measures, and imaging metrics, which address current inadequacies in MS research and clinical needs. Clinical trials are not permitted under this mechanism.
Opportunity ID: 48021
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | W81XWH-09-MSRP-MDVA |
| Funding Opportunity Title: | Multiple Sclerosis Metric Development and Validation Award |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Grant |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | 9 |
| Assistance Listings: | 12.420 — Military Medical Research and Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 18, 2009 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 24, 2009 |
| Current Closing Date for Applications: | Nov 24, 2009 |
| Archive Date: | Dec 24, 2009 |
| Estimated Total Program Funding: | $1,400,000 |
| Award Ceiling: | $0 |
| Award Floor: | $0 |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | Dept. of the Army — USAMRAA |
| Description: | The MSRP Metric Development and Validation Award is being offered for the first time in FY09. The Metric Development and Validation Award is designed to develop and/or validate readily accessible, cost-effective, analytical methods that may be utilized to quantify the disease, monitor disease progress, and/or evaluate the efficacy of disease therapies. Particular emphasis is laid on the development of measurement processes with regard to reproducibility and accuracy and/or the validation of existing and novel measures. Resulting metrics should have broad clinical and/or research applications, as well as the potential for high impact on the MS clinical and/or research community. FY09 DOD Multiple Sclerosis Metric Development and Validation Award 3 Clinical trials are not allowed under this mechanism. Refer to the Application Instructions and General Information, Appendix 6, for additional information on clinical trials. The overall goal of this award is to accelerate advances in MS research. The following are significant features of this award mechanism: 1. Impact: High-impact measurements, if successful, will significantly improve the sensitivity and/or specificity of current methods, or provide methods specific to novel targets, and thereby will enable improved experiments toward the MSRP vision of preventing the occurrence, reversing or slowing the progression and disability, and lessening the impact of MS. Proposals should address a central critical problem or question in MS research. Examples include, but are not limited to, the development of: Metrics for prognosis and/or progression monitoring within individual patients Disease activity or severity metrics for use in longitudinal studies of MS Novel methods for integrating and validating existing data sets Metrics targeting specific subgroups within the MS population (e.g., ethnicity) Quick and inexpensive function-specific measures of physical or cognitive abilities before and after a quantifiable work load 2. Clinical/Research Metrics: It is critical that each proposal address at least one area of MS research in which current measures are inadequate for clinical and/or research needs. Examples of metrics that if systematically validated would be of interest for MS detection and quantification include, but are not limited to: Biometrics: Biomarkers of central nervous system (CNS) autoimmunity, demyelination, axonal degeneration, synaptic regeneration, microbial exposure, nutritional status, gene expression, epigenetics, genetic susceptibility, etc. Cognitive Disability Metrics: Memory attention, visual perception, information processing speed, executive function, etc. Imaging Metrics: Magnetic resonance imaging, optical coherence tomography, positron emission tomography, etc. Multidimensional Metrics: Algorithms using combinations of multiple metrics Physical Disability Metrics: Ease of movement, strength, speed, coordination, dexterity, use of assistive devices, etc. Quality of Life Metrics: Pain, fatigue, sleep disorder, depression, anger, sexual dysfunction, co-morbidities, etc. 3. Preliminary Data: Submission of preliminary data relevant to MS and the proposed project is encouraged but not required. If preliminary data is provided, it must have been generated from the laboratory of the Principal Investigator (PI) or collaborators listed on this award application. Although groundbreaking research often involves a degree of risk due to unforeseen difficulties or results, proposals should be based on a sound scientific rationale FY09 DOD Multiple Sclerosis Metric Development and Validation Award 4 that is established through logical reasoning and/or critical review and analysis of the literature. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
PA HELP: 301-619-7079; cdmrp.pa@amedd.army.mil
eReceipt HELP: 301-682-5507; help@cdmrp.org Email:cdmrp.pa@amedd.army.mil |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 48021 Full Announcement-1 -> msrp fy09 mdva pa final for posting.pdf
Folder 48021 Full Announcement-1 -> biosketchjune09.pdf
Folder 48021 Full Announcement-1 -> budget form reader.pdf
Packages
| Agency Contact Information: | PA HELP: 301-619-7079; cdmrp.pa@amedd.army.mil eReceipt HELP: 301-682-5507; help@cdmrp.org Email: cdmrp.pa@amedd.army.mil |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 12.420 | PKG00012663 | Jun 18, 2009 | Nov 24, 2009 | View |
Package 1
Mandatory forms
48021 RR_SF424-1.1.pdf
48021 RR_PerformanceSite-1.1.pdf
48021 RR_KeyPersonExpanded-1.1.pdf
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