This grant is for advancing the understanding of how genomic variation impacts human health and disease. It seeks applications to experimentally correlate genetic variants with their effects on genomic function and observable traits. Awarded centers will achieve this by systematically perturbing genes, collecting comprehensive data on how non-coding and protein-coding variations influence molecular, cellular, and organismal phenotypes. The initiative aims to generate a comprehensive catalog of these variant effects and contribute to group predictive modeling efforts. Participating centers will join the Impact of Genomic Variation on Function Consortium, collaborating closely to coordinate data collection and analyses strategies, thereby accelerating insights into genomic variation’s role in health and disease.
Opportunity ID: 328538
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HG-20-043 |
| Funding Opportunity Title: | Systematic Characterization of Genomic Variation on Genomic Function and Phenotype (UM1 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 04, 2020 |
| Last Updated Date: | Aug 04, 2020 |
| Original Closing Date for Applications: | Nov 04, 2020 |
| Current Closing Date for Applications: | Nov 04, 2020 |
| Archive Date: | Dec 10, 2020 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments Native American tribal governments (Federally recognized) Small businesses County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | FOA seeks applications to experimentally correlate variants with effects on genomic function. This will be accomplished by performing systematic perturbation; collecting data on the effects of non-coding and protein-coding genomic variation on molecular, cellular, and organismal phenotypes; generating a catalog of these variant effects; and assisting in a group predictive modeling effort using the data. Centers funded through this initiative will become part of the Impact of Genomic Variation on Function Consortium. As members of this Consortium, mapping centers will be expected to work closely with one another and other Consortium components to accelerate understanding of how genomic variation impacts human health and disease through the coordination of data collection strategies and analyses. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-20-043.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or after May 25, 2020 | PKG00262878 | Oct 04, 2020 | Nov 04, 2020 | View |
Package 1
Mandatory forms
328538 RR_SF424_2_0-2.0.pdf
328538 PHS398_CoverPageSupplement_5_0-5.0.pdf
328538 RR_OtherProjectInfo_1_4-1.4.pdf
328538 PerformanceSite_2_0-2.0.pdf
328538 RR_KeyPersonExpanded_2_0-2.0.pdf
328538 RR_Budget_1_4-1.4.pdf
328538 PHS398_ResearchPlan_4_0-4.0.pdf
328538 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
328538 RR_SubawardBudget30_1_4-1.4.pdf
328538 PHS_AssignmentRequestForm_3_0-3.0.pdf
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