The HEAL Initiative is offering this grant for research on understanding inter-individual differences in human pain conditions. This grant aims to advance personalized pain medicine and Whole Person Health by supporting studies that collect clinical/preclinical data. Research should focus on modeling pain heterogeneity related to therapies, comorbid health/mental health conditions, or substance use. Multidisciplinary approaches, incorporating patient and caregiver input, are highly encouraged. The goal is to deepen understanding of the biological and biopsychosocial underpinnings of pain variability, accelerating evidence-based solutions for precision pain management and tailored treatment strategies.
Opportunity ID: 356661
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-NS-25-020 |
| Funding Opportunity Title: | HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 – Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.213 — Research and Training in Complementary and Integrative Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 08, 2024 |
| Last Updated Date: | Oct 08, 2024 |
| Original Closing Date for Applications: | Feb 06, 2025 |
| Current Closing Date for Applications: | Feb 06, 2025 |
| Archive Date: | Mar 14, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) State governments Special district governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public and State controlled institutions of higher education County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This notice of funding opportunity (NOFO) seeks to support research aimed at holistic understanding of inter-individual or between-person differences in human pain conditions, focusing on Whole Person Health and enhancing pain treatment and management strategies towards personalized pain medicine. The goal of this NOFO is to support studies that focus on the collection of clinical and/or preclinical data to enable evidence-based modeling and understanding of inter-individual differences and/or heterogeneity of pain occurring with use of pain therapy/management, or with conditions such as a second pain condition, a comorbid health condition, a comorbid mental health condition, or conditions of use / misuse of opioids, alcohol or other substances. Applicants are encouraged to develop and implement novel, multidisciplinary research approaches, and include investigators with complementary expertise to fulfill the project and program goals. Input from patients and caregivers on the goals of the project is highly encouraged. Rigorous data-driven and evidence-based research approaches supported under this NOFO are expected to provide better understanding of biological and/or biopsychosocial underpinnings of inter-individual differences, heterogeneity, and stratification of persons with lived pain experience, which would accelerate the development of evidence-based solutions toward precision pain medicine. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-25-020.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356661 Full Announcement-RFA-NS-25-020 -> RFA-NS-25-020-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288394 | Jan 06, 2025 | Feb 06, 2025 | View |
Package 1
Mandatory forms
356661 RR_SF424_5_0-5.0.pdf
356661 PHS398_CoverPageSupplement_5_0-5.0.pdf
356661 RR_OtherProjectInfo_1_4-1.4.pdf
356661 PerformanceSite_4_0-4.0.pdf
356661 RR_KeyPersonExpanded_4_0-4.0.pdf
356661 PHS398_ResearchPlan_5_0-5.0.pdf
356661 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356661 RR_Budget_3_0-3.0.pdf
356661 RR_SubawardBudget30_3_0-3.0.pdf
356661 PHS398_ModularBudget_1_2-1.2.pdf
356661 PHS_AssignmentRequestForm_4_0-4.0.pdf
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