This grant is for the purpose of advancing Down Syndrome (DS) research by encouraging innovative projects focused on developing, characterizing, or enhancing animal models and related biological materials. Offered by the INCLUDE Project, this funding opportunity aims to improve access to vital research information and tools. Projects should demonstrate utility for targeted or basic science studies highly relevant to DS. Emphasis is placed on developing diverse animal models, genetic resources, single-cell or subcellular atlases, and leveraging advanced informatics like AI or machine learning. The grant also supports integrating multiple animal models and technology platforms to enhance the rigor and reproducibility of preclinical DS investigations.
Opportunity ID: 357388
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-214 |
| Funding Opportunity Title: | Development of Animal Models and Related Biological Materials for Down Syndrome Research (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.173 — Research Related to Deafness and Communication Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 25, 2024 |
| Last Updated Date: | Nov 25, 2024 |
| Original Closing Date for Applications: | Jan 07, 2026 |
| Current Closing Date for Applications: | Jan 07, 2026 |
| Archive Date: | Feb 12, 2026 |
| Estimated Total Program Funding: | $200,000 |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts State governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments For profit organizations other than small businesses Public housing authorities/Indian housing authorities Special district governments City or township governments Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project encourages exploratory and innovative research to develop, characterize, or improve animal models and related biological materials for Down syndrome (DS) related research and to improve access to information about or from the use of animal models for DS research. The animal models and related biological materials developed must have utility in targeted or basic science studies in areas highly relevant to DS. With this funding opportunity announcement, the INCLUDE Project encourages, but is not limited to, projects focusing on development of various animal models, genetic resources, atlases at a single cell or subcellular level, advanced informatics technologies including artificial intelligence (AI) or machine learning (ML), and integration of multiple animal models and technology platforms for enhancing rigor and reproducibility of preclinical DS research. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-214.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357388 Full Announcement-PAR-25-214 -> PAR-25-214-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289039 | Jan 15, 2025 | Jan 07, 2026 | View |
Package 1
Mandatory forms
357388 RR_SF424_5_0-5.0.pdf
357388 PHS398_CoverPageSupplement_5_0-5.0.pdf
357388 RR_OtherProjectInfo_1_4-1.4.pdf
357388 PerformanceSite_4_0-4.0.pdf
357388 RR_KeyPersonExpanded_4_0-4.0.pdf
357388 PHS398_ResearchPlan_5_0-5.0.pdf
357388 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357388 RR_Budget_3_0-3.0.pdf
357388 RR_SubawardBudget30_3_0-3.0.pdf
357388 PHS398_ModularBudget_1_2-1.2.pdf
357388 PHS_AssignmentRequestForm_4_0-4.0.pdf
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