The INCLUDE Project is offering this grant to develop, characterize, and improve animal models and related biological materials for Down Syndrome (DS) research. This grant is for advancing targeted or basic science studies relevant to DS, and improving access to model-derived information. The Project encourages applications for diverse animal models, genetic resources, single-cell atlases, and advanced informatics (AI/ML). It also seeks projects integrating multiple models and technology platforms to enhance rigor and reproducibility of preclinical DS research, accelerating understanding of co-occurring conditions across the lifespan.
Opportunity ID: 344038
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-247 |
| Funding Opportunity Title: | Development of Animal Models and Related Biological Materials for Down Syndrome Research (R24 Clinical Trials Not-Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.173 — Research Related to Deafness and Communication Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 13, 2022 |
| Last Updated Date: | Oct 13, 2022 |
| Original Closing Date for Applications: | May 25, 2025 |
| Current Closing Date for Applications: | May 25, 2025 |
| Archive Date: | Jun 30, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Public and State controlled institutions of higher education County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Independent school districts |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project encourages grant applications aimed at developing, characterizing, or improving animal models and related biological materials for Down syndrome (DS) related research and improving access to information about or from the use of animal models for DS research. The animal models and related biological materials developed must have utility in targeted or basic science studies in areas highly relevant to DS. With this funding opportunity announcement, the INCLUDE Project encourages, but is not limited to, projects focusing on development of various animal models, genetic resources, atlases at a single cell or subcellular level, advanced informatics technologies including artificial intelligence (AI) or machine learning (ML), and integration of multiple animal models and technology platforms for enhancing rigor and reproducibility of preclinical DS research. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-22-247.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 344038 Full Announcement-PAR-22-247 -> PAR-22-247-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or before January 24, 2025 | PKG00277607 | Nov 01, 2022 | Jan 24, 2025 | View | |
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00277294 | Nov 01, 2022 | Jan 24, 2023 | View | |
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289067 | Nov 26, 2024 | May 25, 2025 | View |
Package 1
Mandatory forms
344038 RR_SF424_5_0-5.0.pdf
344038 PHS398_CoverPageSupplement_5_0-5.0.pdf
344038 RR_OtherProjectInfo_1_4-1.4.pdf
344038 PerformanceSite_4_0-4.0.pdf
344038 RR_KeyPersonExpanded_4_0-4.0.pdf
344038 RR_Budget_3_0-3.0.pdf
344038 PHS398_ResearchPlan_5_0-5.0.pdf
344038 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
344038 RR_SubawardBudget30_3_0-3.0.pdf
344038 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
344038 RR_SF424_5_0-5.0.pdf
344038 PHS398_CoverPageSupplement_5_0-5.0.pdf
344038 RR_OtherProjectInfo_1_4-1.4.pdf
344038 PerformanceSite_4_0-4.0.pdf
344038 RR_KeyPersonExpanded_4_0-4.0.pdf
344038 RR_Budget_3_0-3.0.pdf
344038 PHS398_ResearchPlan_4_0-4.0.pdf
344038 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
344038 RR_SubawardBudget30_3_0-3.0.pdf
344038 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 3
Mandatory forms
344038 RR_SF424_5_0-5.0.pdf
344038 PHS398_CoverPageSupplement_5_0-5.0.pdf
344038 RR_OtherProjectInfo_1_4-1.4.pdf
344038 PerformanceSite_4_0-4.0.pdf
344038 RR_KeyPersonExpanded_4_0-4.0.pdf
344038 RR_Budget_3_0-3.0.pdf
344038 PHS398_ResearchPlan_5_0-5.0.pdf
344038 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
344038 RR_SubawardBudget30_3_0-3.0.pdf
344038 PHS_AssignmentRequestForm_4_0-4.0.pdf
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