This grant, offered by the National Heart, Lung, and Blood Institute, aims to fund comprehensive systems biology studies that utilize multidisciplinary team science to address HIV-associated comorbidities. While previous research often focused on single pathways, this initiative seeks to uncover shared biological mechanisms underlying the development of various comorbidities, particularly in the context of HIV infection. The purpose is to identify common, overlapping etiologies that drive biological aging and age-related comorbidities in people living with HIV. By targeting these shared mechanisms, the grant intends to not only mitigate multiple heart, lung, blood, and sleep (HLBS)-related comorbidities, but also advance understanding of HIV disease pathogenesis and potential cure strategies. The ultimate goal is to identify effective intervention targets.
Opportunity ID: 329265
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-21-027 |
| Funding Opportunity Title: | Multidisciplinary Approaches to HIV-Associated Comorbidities and Prioritizing Intervention Targets (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.233 — National Center on Sleep Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 30, 2020 |
| Last Updated Date: | Sep 30, 2020 |
| Original Closing Date for Applications: | Jan 07, 2023 |
| Current Closing Date for Applications: | Jan 07, 2023 |
| Archive Date: | Feb 12, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $480,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Independent school districts For profit organizations other than small businesses County governments Private institutions of higher education State governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Basic research in the area of HIV-associated comorbidities has generally focused on the analysis of a pathway or a potential mechanism that contributes to the development of a single, specific HIV-associated comorbidity or end-organ disease. However, evidence indicates that there could be shared biological mechanisms that underlie the development of certain comorbidities, especially in the context of HIV infection. Targeting these mechanisms may not only impact HIV-associated comorbidities, but also have an impact on HIV cure and help elucidate underlying mechanisms of HIV disease pathogenesis. Through the formation of multidisciplinary teams, this initiative aims to uncover the pathophysiologic mechanisms that drive biological aging and age-related comorbidities in people living with HIV. This Funding Opportunity Announcement (FOA) seeks applications for comprehensive systems biology studies using multidisciplinary team science to identify common, overlapping etiologies of HIV-associated comorbidities. Ultimately, the goal is to identify targets for intervention to mitigate multiple heart, lung, blood, and sleep (HLBS)-related comorbidities associated with HIV infection. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-21-027.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 329265 Full Announcement-PAR-21-027 -> PAR-21-027-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00263636 | Dec 07, 2020 | Jan 24, 2022 | View | |
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00269784 | Oct 28, 2021 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00277723 | Nov 01, 2022 | Jan 07, 2023 | View |
Package 1
Mandatory forms
329265 RR_SF424_2_0-2.0.pdf
329265 PHS398_CoverPageSupplement_5_0-5.0.pdf
329265 RR_OtherProjectInfo_1_4-1.4.pdf
329265 PerformanceSite_2_0-2.0.pdf
329265 RR_KeyPersonExpanded_2_0-2.0.pdf
329265 PHS398_ResearchPlan_4_0-4.0.pdf
329265 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
329265 RR_Budget_1_4-1.4.pdf
329265 RR_SubawardBudget30_1_4-1.4.pdf
329265 PHS398_ModularBudget_1_2-1.2.pdf
329265 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
329265 RR_SF424_5_0-5.0.pdf
329265 PHS398_CoverPageSupplement_5_0-5.0.pdf
329265 RR_OtherProjectInfo_1_4-1.4.pdf
329265 PerformanceSite_4_0-4.0.pdf
329265 RR_KeyPersonExpanded_4_0-4.0.pdf
329265 PHS398_ResearchPlan_4_0-4.0.pdf
329265 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
329265 RR_Budget_3_0-3.0.pdf
329265 RR_SubawardBudget30_3_0-3.0.pdf
329265 PHS398_ModularBudget_1_2-1.2.pdf
329265 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 3
Mandatory forms
329265 RR_SF424_5_0-5.0.pdf
329265 PHS398_CoverPageSupplement_5_0-5.0.pdf
329265 RR_OtherProjectInfo_1_4-1.4.pdf
329265 PerformanceSite_4_0-4.0.pdf
329265 RR_KeyPersonExpanded_4_0-4.0.pdf
329265 PHS398_ResearchPlan_5_0-5.0.pdf
329265 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
329265 RR_Budget_3_0-3.0.pdf
329265 RR_SubawardBudget30_3_0-3.0.pdf
329265 PHS398_ModularBudget_1_2-1.2.pdf
329265 PHS_AssignmentRequestForm_3_0-3.0.pdf
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