This National Heart, Lung, and Blood Institute (NHLBI) grant is for establishing Clinical Centers in the Severe Asthma Research Program (SARP). The purpose is to develop a new paradigm for understanding severe asthma and its complex, heterogeneous sub-phenotypes in children and adults. Investigators will characterize molecular, cellular, and physiologic phenotypes longitudinally to elucidate evolving pathobiology. This multidisciplinary research aims to enable prediction of phenotype stability and pharmacologic response, and identify novel, disease-modifying targets for treatment. The program emphasizes integrated understanding of severe asthma’s fixed and variable underpinnings, focusing on mechanistic approaches rather than cross-sectional studies or therapeutic trials. Up to six Clinical Centers will collaborate.
Opportunity ID: 54805
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HL-11-018 |
| Funding Opportunity Title: | Clinical Centers for the Severe Asthma Research Program (SARP) (U10) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.838 — Lung Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | May 26, 2010 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Oct 15, 2010 |
| Current Closing Date for Applications: | Oct 15, 2010 |
| Archive Date: | Nov 15, 2010 |
| Estimated Total Program Funding: | $31,500,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Special district governments Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments Public and State controlled institutions of higher education County governments City or township governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. The National Heart, Lung, and Blood Institute invites to participate as a Clinical Center in the NHLBI Severe Asthma Research Program (SARP). Accumulating evidence suggests that severe asthma is complex and phenotypically heterogeneous across individuals and time. Not knowing the underlying mechanisms and stability of these sub-phenotypes impedes the development of effective treatments and management strategies. This phase of SARP will develop a new paradigm for understanding severe asthma and its sub-phenotypes, in children and adults, by defining disease at the molecular and cellular level longitudinally. The new SARP investigators will use mechanistic and evoked phenotype approaches to characterize developmental molecular, cellular and physiologic phenotypes in children and adults with mild to severe asthma and to further elucidate the evolving pathobiology and pathogenesis of severe asthma and its sub-phenotypes. SARP investigators will work together to identify the important research questions that require a shared longitudinal protocol which will be conducted across all participating centers and which will include common information on all SARP participants. In addition, SARP investigators will identify mechanistic research questions separate from those proposed for the shared longitudinal protocol which may be investigated using the shared protocol or in participants from one or more centers. The overall aim is to enable prediction of phenotype stability / fluctuation and pharmacologic response, and to identify novel, disease-modifying targets for treatment. This longitudinal mechanistic research approach will provide integrated understanding of the fixed and variable molecular, cellular, and pathophysiologic underpinnings of severe asthma sub-phenotypes. Cross-sectional studies or therapeutic trials are not the intent of this FOA. This program will require multidisciplinary research collaboration and partnerships between asthma clinician-scientists and scientists with expertise in areas such as immunology, pulmonary physiology, molecular genetics, molecular phenotyping, imaging, and bioinformatics. SARP will consist of up to six Clinical Centers, a Clinical Coordinating Center (CCC), and a Steering Committee. This FOA solicits applications for Clinical Centers and runs parallel with a separate FOA that solicits applications for the Clinical Coordinating Center (see RFA-HL-11-030). |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-11-018.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
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