The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invites applications for the Beta Cell Biology Consortium (BCBC). This U01 grant supports collaborative research to advance cell-replacement therapies for diabetes and improve beta cell mass. Key research areas include differentiating pancreatic beta cells from stem/progenitor cells, stimulating beta cell regeneration in adults, reprogramming cells into beta-cells in-vitro and in-vivo, and investigating human type-1 diabetes progression using patient-derived cells in humanized mouse models. The BCBC is responsible for collaboratively developing essential reagents, protocols, and technologies to facilitate these research efforts. NIDDK expects to award $12 million across 6-10 grants in FY2010, contingent on fund availability.
Opportunity ID: 49096
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DK-09-011 |
| Funding Opportunity Title: | Beta Cell Biology Consortium (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.847 — Diabetes, Endocrinology and Metabolism Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 14, 2009 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Nov 23, 2009 |
| Current Closing Date for Applications: | Nov 23, 2009 |
| Archive Date: | Dec 24, 2009 |
| Estimated Total Program Funding: | $12,000,000 |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Small businesses Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Non-domestic (non-U.S.) Entities (Foreign Organizations); Tribally Controlled Colleges and Universities (TCCUs) . |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. The National Institute of Diabetes and Digestive and Kidney Diseases invite new U01 applications to participate in a consortium of investigators, the Beta Cell Biology Consortium (BCBC); www.betacell.org . The BCBC will work collaboratively to facilitate research in the following areas: 1) use cues from pancreatic development to directly differentiate pancreatic beta cells and islets from stem/progenitor cells for use in cell-replacement therapies for diabetes; 2) determine how to stimulate beta cell regeneration in the adult pancreas as a basis for improving beta cell mass in diabetic patients; 3) determine how to reprogram progenitor/adult cells into pancreatic beta-cells both in-vitro and in-vivo as a mean for developing cell-replacement therapies for diabetes; and 4) investigate the progression of human type-1 diabetes using patient-derived cells and tissues transplanted in humanized mouse models. The BCBC will be responsible for collaboratively generating the necessary reagents, mouse strains, antibodies, assays, protocols, technologies and validation assays that are beyond the scope of any single research effort proposed by the investigators. Mechanism of Support. This FOA will utilize the U01 grant mechanism. Funds Available and Anticipated Number of Awards. The total amount of funding that the NIDDK expects to award through this announcement in FY2010 is $12 million. The anticipated number of awards is 6-10. Although the financial plans of the NIDDK provide support for the first two years of this program, awards pursuant to this FOA, particularly in years 3 to 5 of the awards, are contingent upon the availability of funds. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-09-011.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
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