This grant is for the purpose of encouraging research that will significantly enhance knowledge regarding the mechanisms associated with neuropsychiatric symptoms (NPS) in individuals affected by Alzheimer’s disease (AD) or Alzheimer’s disease-related dementias (ADRD). The primary goal is to advance a deeper mechanistic understanding of both the biobehavioral and neurobiological pathways that contribute to the emergence and progression of NPS. Furthermore, the findings are anticipated to provide crucial insight into the identification of novel therapeutic targets. This foundational research aims to facilitate the development and progression of effective interventions designed specifically to treat and prevent the debilitating development of NPS in patients with AD and/or ADRD.
Opportunity ID: 357199
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-065 |
| Funding Opportunity Title: | Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer’s Dementia (R01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 18, 2024 |
| Last Updated Date: | Nov 18, 2024 |
| Original Closing Date for Applications: | Sep 07, 2026 |
| Current Closing Date for Applications: | Sep 07, 2026 |
| Archive Date: | Oct 13, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Public and State controlled institutions of higher education State governments Small businesses Private institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) City or township governments County governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this Funding Opportunity Announcement (FOA) is to encourage applications for studies that will enhance knowledge of mechanisms associated with neuropsychiatric symptoms (NPS) in persons with Alzheimer’s disease (AD) or Alzheimer’s disease-related dementias (ADRD). The findings are expected to advance mechanistic understanding of both biobehavioral and neurobiological pathways leading to NPS. Findings may also provide insight into novel therapeutic targets that can be advanced into interventions to treat and prevent the development of NPS in AD and/or ADRD |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-065.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357199 Full Announcement-PAR-25-065 -> PAR-25-065-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288787 | Jan 05, 2025 | Sep 07, 2026 | View |
Package 1
Mandatory forms
357199 RR_SF424_5_0-5.0.pdf
357199 PHS398_CoverPageSupplement_5_0-5.0.pdf
357199 RR_OtherProjectInfo_1_4-1.4.pdf
357199 PerformanceSite_4_0-4.0.pdf
357199 RR_KeyPersonExpanded_4_0-4.0.pdf
357199 PHS398_ResearchPlan_5_0-5.0.pdf
357199 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357199 RR_Budget_3_0-3.0.pdf
357199 RR_SubawardBudget30_3_0-3.0.pdf
357199 PHS398_ModularBudget_1_2-1.2.pdf
357199 PHS_AssignmentRequestForm_4_0-4.0.pdf
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