This grant from the National Institute on Aging (NIA) is for funding integrative experimental and analytical research aimed at comprehensively understanding the impact of sex differences on brain aging, disease trajectories, and AD/ADRD risk. It seeks to explore how genes, environment, and host factors like hormonal status interact across various biological complexities, from cellular to population levels. The purpose is to develop robust research programs that illuminate heterogeneous phenotypes of disease risk, individualized prevention strategies, and responsiveness to both pharmacologic and non-pharmacologic interventions for Alzheimer’s disease and AD-related dementias.
Opportunity ID: 357635
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-224 |
| Funding Opportunity Title: | Integrative Research to Understand the Impact of Sex Differences on the Molecular Determinants of AD Risk and Responsiveness to Treatment (U01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 10, 2024 |
| Last Updated Date: | Dec 10, 2024 |
| Original Closing Date for Applications: | Feb 21, 2025 |
| Current Closing Date for Applications: | Feb 21, 2025 |
| Archive Date: | Mar 29, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments For profit organizations other than small businesses Small businesses Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public housing authorities/Indian housing authorities State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Notice of Funding Opportunity (NOFO) invites applications that employ integrative experimental and analytical approaches engaging basic and translational/clinical research aimed at developing a comprehensive understanding of the impact of sex differences on the trajectories of brain aging and disease, phenotypes of AD and AD-related dementias (ADRD) risk, individualized prevention, and responsiveness to pharmacologic and non-pharmacologic interventions. To this end, the central goal of this initiative is to develop robust research programs that will explore how genes, environment, and host factors such as hormonal status (gonadal and brain-derived) interact at various levels of biologic complexity (i.e., cell, tissue, organs/organ systems, and populations) to produce heterogeneous phenotypes of disease risk and responsiveness to prevention/therapy in AD/ADRD. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-224.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357635 Full Announcement-PAR-25-224 -> PAR-25-224-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289567 | Jan 21, 2025 | Feb 21, 2025 | View |
Package 1
Mandatory forms
357635 RR_SF424_5_0-5.0.pdf
357635 PHS398_CoverPageSupplement_5_0-5.0.pdf
357635 RR_OtherProjectInfo_1_4-1.4.pdf
357635 PerformanceSite_4_0-4.0.pdf
357635 RR_KeyPersonExpanded_4_0-4.0.pdf
357635 PHS398_ResearchPlan_5_0-5.0.pdf
357635 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357635 RR_Budget_3_0-3.0.pdf
357635 RR_SubawardBudget30_3_0-3.0.pdf
357635 PHS398_ModularBudget_1_2-1.2.pdf
357635 PHS_AssignmentRequestForm_4_0-4.0.pdf
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