This grant, offered by the National Institutes of Health, supports ancillary studies that leverage ongoing clinical projects and their existing data or cohorts. The purpose of this R21 mechanism funding opportunity is to enable researchers to pursue new, distinct scientific questions that are outside the scope of the original project’s aims, without initiating a new clinical trial. Applicants can utilize established resources to explore novel hypotheses, develop new methodologies, or conduct observational research, thereby maximizing the scientific yield from existing investments in clinical research. This re-issued program incorporates updated ‘Simplified Review’ guidelines, ensuring a streamlined application process. It offers a valuable avenue for expanding knowledge by adding new research dimensions to well-established clinical initiatives.
Opportunity ID: 357591
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-230 |
| Funding Opportunity Title: | Ancillary Studies to Ongoing Clinical Projects (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.846 — Arthritis, Musculoskeletal and Skin Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 09, 2024 |
| Last Updated Date: | Dec 09, 2024 |
| Original Closing Date for Applications: | Dec 05, 2025 |
| Current Closing Date for Applications: | Dec 05, 2025 |
| Archive Date: | Jan 10, 2026 |
| Estimated Total Program Funding: | $250,000 |
| Award Ceiling: | $250,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) State governments Special district governments County governments Independent school districts Public and State controlled institutions of higher education Small businesses Private institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Ancillary Studies to Ongoing Clinical Projects (R21 Clinical Trial Not Allowed) PAR, a re-issue of PAR-23-026, was re-issued as a result of the Simplifying Review of Research Project Grant Applications [link: https://grants.nih.gov/policy-and-compliance/policy-topics/peer-review/simplifying-review]. The Simplified Review changes in Section V are the only changes that have been made. All other aspects of this funding opportunity remain the same. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-230.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357591 Full Announcement-PAR-25-230 -> PAR-25-230-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289521 | Mar 09, 2025 | Dec 05, 2025 | View |
Package 1
Mandatory forms
357591 RR_SF424_5_0-5.0.pdf
357591 PHS398_CoverPageSupplement_5_0-5.0.pdf
357591 RR_OtherProjectInfo_1_4-1.4.pdf
357591 PerformanceSite_4_0-4.0.pdf
357591 RR_KeyPersonExpanded_4_0-4.0.pdf
357591 PHS398_ResearchPlan_5_0-5.0.pdf
357591 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357591 RR_Budget_3_0-3.0.pdf
357591 RR_SubawardBudget30_3_0-3.0.pdf
357591 PHS398_ModularBudget_1_2-1.2.pdf
357591 PHS_AssignmentRequestForm_4_0-4.0.pdf
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