This grant is for establishing Data Analysis and Validation Centers as part of the Molecular Phenotypes of Null Alleles in Cells (MorPhiC) program. The broader MorPhiC initiative aims to create a comprehensive, publicly available catalog of molecular and cellular phenotypes for null alleles across all human genes. This Phase I grant specifically seeks applications to develop robust computational models, data analysis tools, and visualization methods. These centers will be crucial in evaluating the utility and ensuring the quality of the extensive MorPhiC data. The work will contribute to optimizing methods for null allele creation and phenotypic measurement in 1000 protein-coding genes, setting common data formats, and assessing scale limitations for future biomedical research.
Opportunity ID: 335165
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HG-21-030 |
| Funding Opportunity Title: | Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase I: Data Analysis and Validation Centers (U01 Clinical trials not allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 06, 2021 |
| Last Updated Date: | Aug 06, 2021 |
| Original Closing Date for Applications: | Nov 01, 2021 |
| Current Closing Date for Applications: | Nov 01, 2021 |
| Archive Date: | Dec 07, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments For profit organizations other than small businesses Small businesses City or township governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Special district governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public and State controlled institutions of higher education Private institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This FOA is one of three issued to create a new program called “Molecular Phenotypes of Null Alleles in Cells (MorPhiC)”. The long-term goal of MorPhiC is to develop a consistent catalog of molecular and cellular phenotypes for null alleles for every human gene, using in vitro multicellular systems. The catalog will be made available for broad use by the biomedical community. The program will start with a Phase 1 to optimize available methods to create null alleles and measure their phenotypic effects in a target subset of 1000 protein coding genes across the program. Phase I will also assess the scale limitations of such methods, develop common data formats, and establish use cases for this catalog. This specific FOA seeks applications for MorPhiC Data Analysis and Validation Centers. These Centers will develop computational models and data analysis and visualization methods to evaluate and help ensure the utility of the MorPhiC data. Separate FOAs will be issued for the two other components of MorPhiC: Data Production Research and Development Centers and a Data Resource and Administrative Coordination Center to receive, annotate, and present data for consortium and public use and to be the administrative coordinating center for the MorPhiC consortium. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-21-030.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00268470 | Oct 01, 2021 | Jan 24, 2022 | View |
Package 1
Mandatory forms
335165 RR_SF424_2_0-2.0.pdf
335165 PHS398_CoverPageSupplement_5_0-5.0.pdf
335165 RR_OtherProjectInfo_1_4-1.4.pdf
335165 PerformanceSite_2_0-2.0.pdf
335165 RR_KeyPersonExpanded_2_0-2.0.pdf
335165 PHS398_ResearchPlan_4_0-4.0.pdf
335165 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
335165 RR_Budget_1_4-1.4.pdf
335165 RR_SubawardBudget30_1_4-1.4.pdf
335165 PHS398_ModularBudget_1_2-1.2.pdf
335165 PHS_AssignmentRequestForm_3_0-3.0.pdf
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